Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U2SS
|
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| Former ID |
DNC004595
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| Drug Name |
MDL-2170
|
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| Synonyms |
MDL-28170
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Terminated | [545554] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C22H26N2O4
|
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| Canonical SMILES |
CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
|
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| InChI |
1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20+/m0/s1
|
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| InChIKey |
NGBKFLTYGSREKK-VQTJNVASSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Calpain | Target Info | Inhibitor | [529828] | |
| Cathepsin B | Target Info | Inhibitor | [530104] | ||
| Cathepsin L | Target Info | Inhibitor | [530104] | ||
| Cysteine protease falcipain-2 | Target Info | Inhibitor | [528208] | ||
| Reactome | Degradation of the extracellular matrixR-HSA-1442490:Collagen degradation | ||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway | |||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| MHC class II antigen presentation | |||||
| References | |||||
| Ref 528208 | J Med Chem. 2006 Jun 1;49(11):3064-7.Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents. | ||||
| Ref 529828 | Bioorg Med Chem Lett. 2009 Jan 15;19(2):502-7. Epub 2008 Nov 14.Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. | ||||
| Ref 530104 | J Med Chem. 2009 May 14;52(9):3093-7.Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. | ||||
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