Drug Information

Drug General Information
Drug ID
D0V0RS
Former ID
DNC013977
Drug Name
SECOCULARIDINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551362]
Structure
Download
2D MOL

3D MOL
Formula
C20H23NO4
Canonical SMILES
CN(C)CCC1=C2C=CC3=CC(=C(C=C3OC2=C(C=C1)O)OC)OC
InChI
1S/C20H23NO4/c1-21(2)10-9-13-6-8-16(22)20-15(13)7-5-14-11-18(23-3)19(24-4)12-17(14)25-20/h5-8,11-12,22H,9-10H2,1-4H3
InChIKey
DBGGUODEECPLSS-UHFFFAOYSA-N
PubChem Compound ID
44559879
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Inhibitor [551362]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 551362Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.
Ref 551362Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.

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