Target Information
Target General Infomation | |||||
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Target ID |
T55959
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Former ID |
TTDS00017
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Target Name |
Sodium-dependent dopamine transporter
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Gene Name |
SLC6A3
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Synonyms |
DA transporter; DAT; Dopamine transporter; SLC6A3
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Target Type |
Successful
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Disease | Attention deficit hyperactivity disorder [ICD9: 314; ICD10: F90] | ||||
Cocaine addiction [ICD9: 304.2; ICD10: F14.2] | |||||
Dementia [ICD9: 290-294; ICD10: F01-F07] | |||||
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32] | |||||
Mood disorder [ICD10: F30-F39] | |||||
Narcolepsy [ICD9: 347; ICD10: G47.4] | |||||
Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10: I21, I22, R52, R52.1-R52.2, R60.9, G89] | |||||
Obesity [ICD9: 278; ICD10: E66] | |||||
Parkinson's disease [ICD9: 332; ICD10: G20] | |||||
Traumatic brain injury [ICD9: 800.0-801.9, 803.0-804.9, 850.0-854.1; ICD10: S06] | |||||
Function |
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
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BioChemical Class |
Neurotransmitter:sodium symporter
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Target Validation |
T55959
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UniProt ID | |||||
Sequence |
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD RELVDRGEVRQFTLRHWLKV |
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Drugs and Mode of Action | |||||
Drug(s) | Altropane | Drug Info | Approved | Attention deficit hyperactivity disorder | [522203] |
DEXMETHYLPHENIDATE HYDROCHLORIDE | Drug Info | Approved | Attention deficit hyperactivity disorder | [551871] | |
Ioflupane i-123 | Drug Info | Approved | Parkinson's disease | [531783] | |
Methylphenidate | Drug Info | Approved | Attention deficit hyperactivity disorder | [536713], [542252] | |
Modafinil | Drug Info | Approved | Narcolepsy | [551871] | |
Methylphenidate | Drug Info | Phase 4 | Traumatic brain injury | [536120], [542252] | |
Amitifadine | Drug Info | Phase 3 | Obesity | [527289], [528424] | |
Dasotraline | Drug Info | Phase 3 | Mood disorder | [524969], [543060] | |
NAV5001 | Drug Info | Phase 3 | Dementia | [524446] | |
Amfetamine transdermal | Drug Info | Phase 2 | Attention deficit hyperactivity disorder | [524098] | |
METHYLENEDIOXYMETHAMPHETAMINE | Drug Info | Phase 2 | Discovery agent | [521857] | |
GSK-1360707 | Drug Info | Phase 1 | Major depressive disorder | [523095] | |
RTI-336 | Drug Info | Phase 1 | Cocaine addiction | [536187] | |
Manifaxine | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [546210] | |
NS-2389 | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [546575] | |
SPD-473 | Drug Info | Discontinued in Phase 2 | Mood disorder | [546832] | |
KP106 | Drug Info | Discontinued in Phase 1 | Attention deficit hyperactivity disorder | [548965] | |
NSD-644 | Drug Info | Discontinued in Phase 1 | Neurological disease | [548670] | |
RG-7166 | Drug Info | Discontinued in Phase 1 | Major depressive disorder | [549027] | |
Vanoxerine | Drug Info | Discontinued in Phase 1 | Cocaine addiction | [536187] | |
Fluoratec | Drug Info | Terminated | Attention deficit hyperactivity disorder | [547430] | |
Seridopidine | Drug Info | Terminated | Neurological disease | [546992] | |
Inhibitor | (+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine | Drug Info | [530012] | ||
(+/-)-threo-3',4'-Dichloromethylphenidate amide | Drug Info | [531163] | |||
(+/-)-threo-3',4'-Dichlororitalinol | Drug Info | [531163] | |||
(+/-)-threo-3',4'-Dichlororitalinol methyl ether | Drug Info | [531163] | |||
(+/-)-threo-3',5'-Dichloromethylphenidate | Drug Info | [531163] | |||
(+/-)-threo-3',5'-Dimethylmethylphenidate | Drug Info | [531163] | |||
(+/-)-threo-3-Fluororitalinol | Drug Info | [531163] | |||
(+/-)-threo-4'-Ethylmethylphenidate | Drug Info | [531163] | |||
(+/-)-threo-Benzylphenidate | Drug Info | [531163] | |||
(+/-)-threo-Methylphenidate amide | Drug Info | [531163] | |||
(+/-)-threo-N-(2-Chlorobenzyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(2-Methylfuran)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(2-Methylpyridine)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(2-Methylthiopene)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(2-Phenylethyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(2-Phenylethyl)ritalinol | Drug Info | [531163] | |||
(+/-)-threo-N-(3-Chlorobenzyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(3-Methylfuran)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(3-Methylpyridine)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(3-Methylthiopene)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(3-Phenylpropyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(3-Phenylpropyl)ritalinol | Drug Info | [531163] | |||
(+/-)-threo-N-(4-Chlorobenzyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(4-Methoxybenzyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(4-Methylpyridine)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(4-Nitrobenzyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(4-Phenylbutyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(4-Phenylbutyl)ritalinol | Drug Info | [531163] | |||
(+/-)-threo-N-(5-Phenylpentyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-(6-Phenylhexyl)methylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-Allylmethylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-Benzyl-3',4'-dichlororitalinol | Drug Info | [531163] | |||
(+/-)-threo-N-Benzyl-3'-chloromethylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-Benzylmethylphenidate amide | Drug Info | [531163] | |||
(+/-)-threo-N-Ethylritalinol | Drug Info | [531163] | |||
(+/-)-threo-N-Methyl-30-methylmethylphenidate | Drug Info | [531163] | |||
(+/-)-threo-N-Propargylmethylphenidate | Drug Info | [531163] | |||
(+/-)-threo-Ritalinol | Drug Info | [531163] | |||
(+/-)-threo-Ritalinol methyl ether | Drug Info | [531163] | |||
(1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine | Drug Info | [535513] | |||
(2R,3R)-iodoreboxetine | Drug Info | [529666] | |||
(2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine | Drug Info | [530282] | |||
(2R,3S)-2-[(3-Iodophenoxy)phenylmethyl]morpholine | Drug Info | [530282] | |||
(2R,3S)-2-[(4-Iodophenoxy)phenylmethyl]morpholine | Drug Info | [530282] | |||
(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol | Drug Info | [530946] | |||
(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol | Drug Info | [530946] | |||
(2S,3S)-iodoreboxetine | Drug Info | [529666] | |||
(cis)-1,6-diphenyl-3-aza-bicyclo[3.1.0]hexane | Drug Info | [529523] | |||
(R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol | Drug Info | [530918] | |||
(R)-3-(naphthalen-2-ylmethoxy)pyrrolidine | Drug Info | [530012] | |||
(R)-DULOXETINE | Drug Info | [529824] | |||
(R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide | Drug Info | [530367] | |||
(R)-Norfluoxetine | Drug Info | [529814] | |||
(RS/SR)-2-[1-(3,4-dichlorophenyl)butyl]piperidine | Drug Info | [528619] | |||
(RS/SR)-2-[1-(4-chlorophenyl)butyl]piperidine | Drug Info | [528619] | |||
(RS/SR)-2-[1-(4-chlorophenyl)ethyl]piperidine | Drug Info | [528619] | |||
(RS/SR)-2-[1-(4-chlorophenyl)hexyl]piperidine | Drug Info | [528619] | |||
(RS/SR)-2-[1-(4-chlorophenyl)pentyl]piperidine | Drug Info | [528619] | |||
(RS/SR)-2-[1-(4-chlorophenyl)propyl]piperidine | Drug Info | [528619] | |||
(S)-3-(naphthalen-2-ylmethoxy)pyrrolidine | Drug Info | [530012] | |||
(S)-Norfluoxetine | Drug Info | [529814] | |||
1-(1,4-diphenylbutan-2-yl)piperazine | Drug Info | [528226] | |||
1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | Drug Info | [530918] | |||
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine | Drug Info | [529569] | |||
1-(1-Benzo[b]thiophen-2-yl-cycloheptyl)-azepane | Drug Info | [533891] | |||
1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-azepane | Drug Info | [533891] | |||
1-(1-Benzo[b]thiophen-2-yl-cyclopentyl)-azepane | Drug Info | [533891] | |||
1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | Drug Info | [530918] | |||
1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine | Drug Info | [533479] | |||
1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | Drug Info | [530918] | |||
1-(2-(2-chlorophenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(4-fluorophenoxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(phenoxymethyl)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(2-phenoxyphenyl)piperazine | Drug Info | [530474] | |||
1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol | Drug Info | [527062] | |||
1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol | Drug Info | [527062] | |||
1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane | Drug Info | [529523] | |||
1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one | Drug Info | [530728] | |||
1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one | Drug Info | [530728] | |||
1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one | Drug Info | [530728] | |||
1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-aminophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [530137] | |||
1-(4-bromophenyl)-2-(tert-butylamino)propan-1-one | Drug Info | [530728] | |||
1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane | Drug Info | [529523] | |||
1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane | Drug Info | [529523] | |||
1-(thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexane | Drug Info | [529523] | |||
1-Benzo[b]thiophen-2-yl-cycloheptylamine | Drug Info | [533891] | |||
1-Benzo[b]thiophen-2-yl-cyclohexylamine | Drug Info | [533891] | |||
1-Benzo[b]thiophen-2-yl-cyclopentylamine | Drug Info | [533891] | |||
1-benzylpiperidine hydrochloride | Drug Info | [528826] | |||
1-Biphenyl-4-yl-3-aza-bicyclo[3.1.0]hexane | Drug Info | [529523] | |||
1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-phenyl-1-(piperidin-2-yl)propan-2-one | Drug Info | [528619] | |||
1-phenyl-3-aza-bicyclo[3.1.0]hexane | Drug Info | [529523] | |||
10R-hydroxylobel-7-ene | Drug Info | [528364] | |||
10R-hydroxylobelane | Drug Info | [528364] | |||
10S-hydroxylobel-7-ene | Drug Info | [528364] | |||
10S-hydroxylobelane | Drug Info | [528364] | |||
1S,2R-milnacipran | Drug Info | [529776] | |||
2-((2-iodophenoxy)(phenyl)methyl)morpholine | Drug Info | [528517] | |||
2-((3-iodophenyl)(o-tolyloxy)methyl)morpholine | Drug Info | [528517] | |||
2-(2'-Aminoethyl)-5-benzyltetrahydrofuran | Drug Info | [529955] | |||
2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info | [533479] | |||
2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(Aminomethyl)-5-(1'-naphthyl)tetrahydrofuran | Drug Info | [529955] | |||
2-(Aminomethyl)-5-(2'-naphthyl)tetrahydrofuran | Drug Info | [529955] | |||
2-(Aminomethyl)-5-phenethyltetrahydrofuran | Drug Info | [529955] | |||
2-(N,N-Diethylamino)-3'-chloropropiophenone | Drug Info | [530442] | |||
2-(N-Cyclopentylamino)-3'-bromopropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopentylamino)-3'-chloropropiophenone | Drug Info | [530442] | |||
2-(N-Cyclopentylamino)-3'-fluoropropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopentylamino)-3'-methoxypropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopentylamino)-3'-methylpropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopropylamino)-3-chloropropiophenone | Drug Info | [530442] | |||
2-(N-Isopropylamino)-3'-chloropropiophenone | Drug Info | [530442] | |||
2-(N-Pyrrolidinyl)-3'-bromopropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-fluoropropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-methoxypropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-methylpropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-nitropropiophenone | Drug Info | [530728] | |||
2-(N-tert-Butylamino)-3',4'-dichloropropiophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chloroheptanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chlorohexanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chlorooctanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chloropentanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-4'-chloropropiophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)propiophenone | Drug Info | [530442] | |||
2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one | Drug Info | [530728] | |||
2-(tert-butylamino)-1-m-tolylpropan-1-one | Drug Info | [530728] | |||
2-(tert-butylamino)-1-p-tolylpropan-1-one | Drug Info | [530728] | |||
2-(tert-Butylamino)-3',4'-dichlorobutyrophenone | Drug Info | [530442] | |||
2-(tert-Butylamino)-3',4'-dichloropentanophenone | Drug Info | [530442] | |||
2-(tert-Butylamino)-3',5'-difluoropropiophenone | Drug Info | [530442] | |||
2-(tert-Butylamino)-3'-fluoropropiophenone | Drug Info | [530442] | |||
2-Amino-1-(4-methylthiophenyl)propane | Drug Info | [530347] | |||
2-Aminomethyl-5-(p-bromophenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(p-chlorophenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(p-t-butylphenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(phenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-phenoxy-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-phenylpiperidine hydrochloride | Drug Info | [528826] | |||
2pyrrolidin-1-yl-1-phenylpentan-1-one | Drug Info | [528036] | |||
3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol | Drug Info | [528224] | |||
3-(3,4-dichlorophenyl)-2-nortropene | Drug Info | [530502] | |||
3-(4-Chlorophenyl)-2-nortropene | Drug Info | [530502] | |||
3-(4-Fluorophenyl)-2-nortropene | Drug Info | [530502] | |||
3-(4-Trifluoromethylphenyl)-2-nortropene | Drug Info | [530502] | |||
3-alpha-Phenylmethoxy-3-beta-phenyl-nortropane | Drug Info | [530502] | |||
3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | Drug Info | [525906] | |||
3-Phenyl-2-nortropene | Drug Info | [530502] | |||
3alpha-(bis-chloro-phenylmethoxy)tropane | Drug Info | [528473] | |||
4-(1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine | Drug Info | [528760] | |||
4-(2-((3-fluorophenoxy)methyl)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(2-fluorobenzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-chlorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorobenzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorophenoxy)-4-methylphenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)-3-fluorophenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)-6-fluorophenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(phenoxymethyl)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine | Drug Info | [530596] | |||
4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(2-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(2-pyrrolidin-1-yl-pentanoyl)benzonitrile | Drug Info | [528036] | |||
4-(3-fluoro-2-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one | Drug Info | [531079] | |||
6-(3-aza-bicyclo[3.1.0]hexan-1-yl)quinoline | Drug Info | [529523] | |||
6-(piperidin-4-ylmethoxy)-2-naphthonitrile | Drug Info | [530012] | |||
7-(piperidin-4-ylmethoxy)-2-naphthonitrile | Drug Info | [530012] | |||
8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane | Drug Info | [525906] | |||
8R-hydroxylobel-9-ene | Drug Info | [530601] | |||
8R-hydroxylobelane | Drug Info | [528364] | |||
8S-hydroxylobel-9-ene | Drug Info | [528364] | |||
8S-hydroxylobelane | Drug Info | [528364] | |||
Altropane | Drug Info | [534626] | |||
Amfetamine transdermal | Drug Info | [531141] | |||
AMINOBENZTROPINE | Drug Info | [534349] | |||
Amitifadine | Drug Info | [543975] | |||
ANOLOBINE | Drug Info | [551362] | |||
ANONAINE | Drug Info | [551362] | |||
ANTIOQUINE | Drug Info | [551362] | |||
Benzhydryl-(2-phenyl-quinazolin-4-yl)-amine | Drug Info | [535513] | |||
Benzyl-(2-phenyl-quinazolin-4-yl)-amine | Drug Info | [535513] | |||
Bip-tyr(3bzl)-thr-pro-lys-thr | Drug Info | [528289] | |||
Bip-tyr-ala-pro-lys-thr(obzl)-gly | Drug Info | [528289] | |||
Bip-tyr-thr-ala-pro-phe | Drug Info | [528289] | |||
Bip-tyr-thr-pro-ala-thr(obzl)-gly | Drug Info | [528289] | |||
Bip-tyr-thr-pro-lys-thr | Drug Info | [528289] | |||
Bip-tyr-thr-pro-lys-thr(obzl)-gly | Drug Info | [528289] | |||
Bip-tyr-thr-pro-thr(obzl)-gly | Drug Info | [528289] | |||
Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine | Drug Info | [529592] | |||
Cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine | Drug Info | [529530] | |||
COCAINE.HCL | Drug Info | [528826] | |||
COCLAURINE | Drug Info | [551362] | |||
compound 58 | Drug Info | [532887] | |||
D-166A | Drug Info | [529287] | |||
D-211A | Drug Info | [529287] | |||
D-211B | Drug Info | [529287] | |||
D-254C | Drug Info | [529287] | |||
D-257A | Drug Info | [529287] | |||
D-257C | Drug Info | [529287] | |||
Dasotraline | Drug Info | [533235] | |||
DEXMETHYLPHENIDATE HYDROCHLORIDE | Drug Info | [528826] | |||
DIFLUOROBENZTROPINE | Drug Info | [528473] | |||
DIMETHYLGRISABINE | Drug Info | [551362] | |||
Erythro-3,4-dichloromethylphenidate hydrochloride | Drug Info | [528826] | |||
GB-12819 | Drug Info | [526396] | |||
GSK-1360707 | Drug Info | [532361] | |||
HOMOAROMOLINE | Drug Info | [551362] | |||
ISOPILINE | Drug Info | [551362] | |||
ISOTETRANDRINE | Drug Info | [551362] | |||
Methyl 2-(naphthalen-2-yl)benzoate | Drug Info | [528794] | |||
METHYLENEDIOXYAMPHETAMINE | Drug Info | [530914] | |||
METHYLENEDIOXYMETHAMPHETAMINE | Drug Info | [530347] | |||
N,Ndimethyl milnacipran | Drug Info | [529263] | |||
N-Benzylmethylphenidate | Drug Info | [531163] | |||
NISOXETINE | Drug Info | [529530] | |||
NORBOLDINE | Drug Info | [551362] | |||
NORSTEPHALAGINE | Drug Info | [551362] | |||
O-2442 | Drug Info | [543975] | |||
O-methyldauricine | Drug Info | [551362] | |||
OBABERINE | Drug Info | [551362] | |||
Para-chloroamphetamine | Drug Info | [530347] | |||
PF-18298 | Drug Info | [530918] | |||
PF-3409409 | Drug Info | [530265] | |||
PF-526014 | Drug Info | [530918] | |||
PSEUDOCOCAINE | Drug Info | [525537] | |||
PYROVALERONE | Drug Info | [530137] | |||
R-226161 | Drug Info | [528772] | |||
R-NORDULOXETINE | Drug Info | [530368] | |||
RG-7166 | Drug Info | [549028] | |||
RTI-219 | Drug Info | [528932] | |||
SECOCULARIDINE | Drug Info | [551362] | |||
SPD-473 | Drug Info | [527287] | |||
Threo-1-aza-5-phenyl[4.4.0]decane hydrochloride | Drug Info | [528826] | |||
Threo-3,4-dichlororitalinol hydrochloride | Drug Info | [528826] | |||
Threo-N-ethylritalinol hydrochloride | Drug Info | [528826] | |||
Threo-ritalinol hydrochloride | Drug Info | [528826] | |||
Threo-ritalinol methyl ether hydrochloride | Drug Info | [528826] | |||
Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine | Drug Info | [529530] | |||
WIN-35065 | Drug Info | [528932] | |||
WIN-35065-2 | Drug Info | [534240] | |||
WIN-35066-2 | Drug Info | [527309] | |||
WIN_35428 | Drug Info | [534240] | |||
[3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine | Drug Info | [527062] | |||
[3H]GBR12935 | Drug Info | [533984] | |||
[3H]WIN35428 | Drug Info | [533984] | |||
[N-[2-[(3'-N'-PROPYL-3''ALPHA-(BIS(4-FLUORORPHENYL)METHOXY)TROPANE-2''BETA-CARBOXYLIC ACID METHYL ESTER)(2-MERCAPTOETHYL)AMINO]ACETYL]-2-AMINOETHANETHIOLATO]RHENIUM(V) OXIDE (DIASTEREOMERIC MIX) | Drug Info | [534407] | |||
Modulator | 3,4-Methylenedioxymethamphetamine | Drug Info | [551382] | ||
Fluoratec | Drug Info | [534375] | |||
Ioflupane i-123 | Drug Info | [551871] | |||
Manifaxine | Drug Info | [527845] | |||
MMDA | Drug Info | [551393] | |||
Modafinil | Drug Info | [556264] | |||
NAV5001 | Drug Info | [534626] | |||
NS-2389 | Drug Info | [550007] | |||
RTI-336 | Drug Info | ||||
Seridopidine | Drug Info | [533284] | |||
Antagonist | 4-Methoxyamphetamine | Drug Info | [551380] | ||
Agonist | KP106 | Drug Info | [551554] | ||
Blocker | Methylphenidate | Drug Info | [536100] | ||
Vanoxerine | Drug Info | [536187] | |||
Activator | NSD-644 | Drug Info | [550360] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Dopaminergic synapse | ||||
Parkinson' | |||||
s disease | |||||
Cocaine addiction | |||||
Amphetamine addiction | |||||
Alcoholism | |||||
PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
Parkinson disease | |||||
Dopamine receptor mediated signaling pathway | |||||
Pathway Interaction Database | Alpha-synuclein signaling | ||||
Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
WikiPathways | Monoamine Transport | ||||
NRF2 pathway | |||||
Dopaminergic Neurogenesis | |||||
Parkinsons Disease Pathway | |||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
Neurotransmitter Clearance In The Synaptic Cleft | |||||
References | |||||
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