Drug General Information
Drug ID	D0O6QW
Former ID	DIB014579
Drug Name	Manifaxine
Synonyms	BW-1555U88; GW-320659; GW-320659A
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Discontinued in Phase 2	[546210]
Company	Glaxo Wellcome plc
Structure		Download 2D MOL 3D MOL
Formula	C12H15F2NO2
Canonical SMILES	[C@]1(c2cc(cc(c2)F)F)(OC[C@H](N[C@H]1C)C)O
PubChem Compound ID	6433078
Target and Pathway
Target(s)	Sodium-dependent noradrenaline transporter	Target Info	Modulator	[527845]
	Sodium-dependent dopamine transporter	Target Info	Modulator	[527845]
KEGG Pathway	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 546210	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006906)
Ref 527845	Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005 Dec;15(12):883-9.

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