Target Information
Target General Infomation | |||||
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Target ID |
T21945
|
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Former ID |
TTDC00304
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Target Name |
Sodium-dependent noradrenaline transporter
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Gene Name |
SLC6A2
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Synonyms |
NET; Norepinephrine transporter; SLC6A2
|
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Target Type |
Successful
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Disease | Attention deficit hyperactivity disorder; Depression; Cocaine addiction [ICD9: 303-304, 304.2, 311, 314.00, 314.01; ICD10: F10-F19, F14.2, F32, F90] | ||||
Attention deficit hyperactivity disorder [ICD9: 314; ICD10: F90] | |||||
Attention deficit hyperactivity disorder; Severe mood disorders [ICD9: 296, 314.00, 314.01; ICD10: F30-F39, F90] | |||||
Anesthesia; Ocular disease [ICD9:338; ICD10: R20.0, H00-H59] | |||||
Cancer pain [ICD9: 140-229, 338,780; ICD10: R52, G89] | |||||
Chronic low back pain; Neuropathic pain [ICD9: 338, 356.0, 356.8, 724.2, 724.5,780; ICD10: G64, G90.0, M54, M54.5, R52, G89] | |||||
Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3] | |||||
Depression; Attention deficit hyperactivity disorder [ICD9: 311, 314.00, 314.01; ICD10: F30-F39, F90] | |||||
Depression [ICD9: 311; ICD10: F30-F39] | |||||
Depression; Bipolar disorder [ICD9:311, 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10: F30-F39, F31, F40-F42] | |||||
Depression; Chronic pain [ICD9: 311, 338,780; ICD10: F30-F39, R52, G89] | |||||
Depression; Attention deficit hyperactivity disorder [ICD9:311, 314; ICD10: F30-F39, F90] | |||||
Depression; Anxiety disorder [ICD9:311, 300; ICD10: F30-F39, F32, F40-F42] | |||||
Fibromyalgia [ICD9: 729.1; ICD10: M79.7] | |||||
Fatigue [ICD10: R53] | |||||
Glaucoma [ICD9: 365; ICD10: H40-H42] | |||||
Heart failure diagnosis [ICD9: 428; ICD10: I50] | |||||
Heart failure [ICD9: 428; ICD10: I50] | |||||
Moderate-to-severe acute pain [ICD9: 338,780; ICD10: R52, G89] | |||||
Mood disorder [ICD10: F30-F39] | |||||
Migraine; Obisity [ICD9: 278, 346; ICD10: E66, G43] | |||||
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32] | |||||
Neuroendocrine cancer [ICD10: C7A] | |||||
Neuroblastoma [ICD9: 194.0, 194.5, 194.6, 227.0, 227.5, 227.6, 237.3, 255.6; ICD10: C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7] | |||||
Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10: I21, I22, R52, R52.1-R52.2, R60.9, G89] | |||||
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | |||||
Obesity [ICD9: 278; ICD10: E66] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Smoking cessation [ICD9: 292; ICD10: F17.2] | |||||
Severe mood disorders [ICD9: 296; ICD10: F30-F39] | |||||
Unspecified [ICD code not available] | |||||
Function |
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
|
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BioChemical Class |
Neurotransmitter:sodium symporter
|
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Target Validation |
T21945
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UniProt ID | |||||
Sequence |
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL VAQRDIRQFQLQHWLAI |
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Drugs and Mode of Action | |||||
Drug(s) | Amfepramone | Drug Info | Approved | Obesity | [536103] |
Amitriptyline | Drug Info | Approved | Depression; Chronic pain | [536306], [539289], [551871] | |
Amoxapine | Drug Info | Approved | Major depressive disorder | [538247], [539292], [551871] | |
Atomoxetine | Drug Info | Approved | Attention deficit hyperactivity disorder | [536661], [542125] | |
Bupropion | Drug Info | Approved | Smoking cessation | [551871] | |
Cocaine | Drug Info | Approved | Anesthesia; Ocular disease | [539436], [550681], [551871] | |
Desipramine | Drug Info | Approved | Depression; Attention deficit hyperactivity disorder | [536306], [539526], [551871] | |
Desvenalfaxine succinate | Drug Info | Approved | Fibromyalgia | [536647] | |
Diethylpropion | Drug Info | Approved | Migraine; Obisity | [536661], [542170] | |
Duloxetine | Drug Info | Approved | Depression | [536306], [539298] | |
Imipramine | Drug Info | Approved | Depression; Anxiety disorder | [536306], [540475], [551871] | |
Iobenguane I 123 injection | Drug Info | Approved | Heart failure diagnosis | [524423], [551871] | |
Iobenguane I-123 | Drug Info | Approved | Neuroendocrine cancer | [529941] | |
Iobenguane I-123 - GE Healthcare | Drug Info | Approved | Unspecified | [551871] | |
Levomilnacipran | Drug Info | Approved | Fibromyalgia | [530677], [542458] | |
Maprotiline | Drug Info | Approved | Major depressive disorder | [551871] | |
Mazindol | Drug Info | Approved | Obesity | [468026], [535114] | |
Milnacipran | Drug Info | Approved | Depression | [536580], [542459] | |
Phenmetrazine | Drug Info | Approved | Obesity | [550743] | |
Phentermine | Drug Info | Approved | Obesity | [536710], [542288] | |
Protriptyline | Drug Info | Approved | Depression; Bipolar disorder | [536306], [542305], [551871] | |
Reboxetine | Drug Info | Approved | Depression | [468039], [536306] | |
Sibutramine | Drug Info | Approved | Obesity | [536710], [539665] | |
Tapentadol hydrochloride | Drug Info | Approved | Moderate-to-severe acute pain | [529941] | |
Trimipramine | Drug Info | Approved | Major depressive disorder | [551871] | |
Ultracet | Drug Info | Approved | Pain | [536242] | |
Venlafaxine | Drug Info | Approved | Depression | [537533], [542345] | |
Hypericum | Drug Info | Phase 4 | Discovery agent | [522154] | |
Amitifadine | Drug Info | Phase 3 | Obesity | [527289], [528424] | |
Bicifadine | Drug Info | Phase 3 | Chronic low back pain; Neuropathic pain | [536374] | |
Bupropion+naltrexone | Drug Info | Phase 3 | Obesity | [532233] | |
Dasotraline | Drug Info | Phase 3 | Mood disorder | [524969], [543060] | |
Roclatan | Drug Info | Phase 3 | Glaucoma | [525325] | |
Suronacrine maleate | Drug Info | Phase 3 | Cognitive disorders | [551848] | |
18F-LMI-1195 | Drug Info | Phase 2 | Heart failure | [522972] | |
DOV 21947 | Drug Info | Phase 2 | Severe mood disorders | [536580] | |
MCT-125 | Drug Info | Phase 2 | Fatigue | [548187] | |
Metaiodobenzylguanidine I-131 | Drug Info | Phase 2 | Neuroblastoma | [545811] | |
METHYLENEDIOXYMETHAMPHETAMINE | Drug Info | Phase 2 | Discovery agent | [521857] | |
Rhopressa | Drug Info | Phase 2 | Glaucoma | [533091] | |
TD-9855 | Drug Info | Phase 2 | Pain | [533083] | |
XEN-2174 | Drug Info | Phase 2 | Cancer pain | [548033] | |
BL-1021 | Drug Info | Phase 1 | Pain | [523040] | |
GSK-1360707 | Drug Info | Phase 1 | Major depressive disorder | [523095] | |
DOV-216303 | Drug Info | Discontinued in Phase 2 | Severe mood disorders | [536580] | |
Esreboxetine | Drug Info | Discontinued in Phase 2 | Fibromyalgia | [549540] | |
GSK372475 | Drug Info | Discontinued in Phase 2 | Attention deficit hyperactivity disorder; Severe mood disorders | [533085] | |
Manifaxine | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [546210] | |
Napitane mesilate | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [545865] | |
NS 2359 | Drug Info | Discontinued in Phase 2 | Attention deficit hyperactivity disorder; Depression; Cocaine addiction | [536580] | |
NS-2389 | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [546575] | |
R-sibutramine metabolite | Drug Info | Discontinued in Phase 2 | Depression; Attention deficit hyperactivity disorder | [536580] | |
Radafaxine | Drug Info | Discontinued in Phase 2 | Major depressive disorder | [536295] | |
SPD-473 | Drug Info | Discontinued in Phase 2 | Mood disorder | [546832] | |
NSD-644 | Drug Info | Discontinued in Phase 1 | Neurological disease | [548670] | |
Radaxafine HCl | Drug Info | Discontinued in Phase 1 | Neuropathic pain | [536374] | |
RG-7166 | Drug Info | Discontinued in Phase 1 | Major depressive disorder | [549027] | |
Inhibitor | ((3R,4R)-4-(o-tolyloxy)chroman-3-yl)methanamine | Drug Info | [529620] | ||
(+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine | Drug Info | [530012] | |||
(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol | Drug Info | [530946] | |||
(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol | Drug Info | [530946] | |||
(R)-1-((S)-morpholin-2-yl)-1,2-diphenylethanol | Drug Info | [527968] | |||
(R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol | Drug Info | [530918] | |||
(R)-3-(naphthalen-2-ylmethoxy)pyrrolidine | Drug Info | [530012] | |||
(R)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile | Drug Info | [530012] | |||
(R)-DULOXETINE | Drug Info | [530368] | |||
(R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide | Drug Info | [530367] | |||
(R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide | Drug Info | [530367] | |||
(R)-Norfluoxetine | Drug Info | [529814] | |||
(S)-3-(naphthalen-2-ylmethoxy)pyrrolidine | Drug Info | [530012] | |||
(S)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile | Drug Info | [530012] | |||
(S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide | Drug Info | [530367] | |||
(S)-NORDULOXETINE | Drug Info | [530368] | |||
(S)-Norfluoxetine | Drug Info | [529814] | |||
1-(1,2-diphenylethyl)piperazine | Drug Info | [528224] | |||
1-(1,4-diphenylbutan-2-yl)piperazine | Drug Info | [528226] | |||
1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | Drug Info | [530918] | |||
1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) | Drug Info | [530918] | |||
1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | Drug Info | [530918] | |||
1-(1-phenyl-2-o-tolylethyl)piperazine | Drug Info | [528224] | |||
1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine | Drug Info | [533479] | |||
1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) | Drug Info | [530918] | |||
1-(2-(2-bromophenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine | Drug Info | [530596] | |||
1-(2-(2-chlorophenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(2-ethoxyphenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(2-ethylphenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(2-fluorobenzyloxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine | Drug Info | [530918] | |||
1-(2-(3-chlorophenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(3-fluorophenoxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(3-methoxyphenyl)-1-phenylethyl)piperazine | Drug Info | [528224] | |||
1-(2-(4-fluorophenoxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine | Drug Info | [530012] | |||
1-(2-(benzyloxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(phenoxymethyl)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(2-phenoxyphenyl)piperazine | Drug Info | [530474] | |||
1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol | Drug Info | [527062] | |||
1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol | Drug Info | [527062] | |||
1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane | Drug Info | [531114] | |||
1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one | Drug Info | [530728] | |||
1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one | Drug Info | [530728] | |||
1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one | Drug Info | [530728] | |||
1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-bromophenyl)-2-(tert-butylamino)propan-1-one | Drug Info | [530728] | |||
1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-(4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one | Drug Info | [528036] | |||
1S,2R-milnacipran | Drug Info | [529776] | |||
2-((2-iodophenoxy)(phenyl)methyl)morpholine | Drug Info | [528517] | |||
2-((3-iodophenyl)(o-tolyloxy)methyl)morpholine | Drug Info | [528517] | |||
2-(2'-Aminoethyl)-5-benzyltetrahydrofuran | Drug Info | [529955] | |||
2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info | [533479] | |||
2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile | Drug Info | [528224] | |||
2-(Aminomethyl)-5-(1'-naphthethyl)tetrahydrofuran | Drug Info | [529955] | |||
2-(Aminomethyl)-5-(1'-naphthyl)tetrahydrofuran | Drug Info | [529955] | |||
2-(Aminomethyl)-5-(2'-naphthyl)tetrahydrofuran | Drug Info | [529955] | |||
2-(Aminomethyl)-5-phenethyltetrahydrofuran | Drug Info | [529955] | |||
2-(N,N-Diethylamino)-3'-chloropropiophenone | Drug Info | [530442] | |||
2-(N-Cyclopentylamino)-3'-bromopropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopentylamino)-3'-chloropropiophenone | Drug Info | [530442] | |||
2-(N-Cyclopentylamino)-3'-fluoropropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopentylamino)-3'-methoxypropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopentylamino)-3'-methylpropiophenone | Drug Info | [530728] | |||
2-(N-Cyclopropylamino)-3-chloropropiophenone | Drug Info | [530442] | |||
2-(N-Pyrrolidinyl)-3'-bromopropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-fluoropropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-methoxypropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-methylpropiophenone | Drug Info | [530728] | |||
2-(N-Pyrrolidinyl)-3'-nitropropiophenone | Drug Info | [530728] | |||
2-(N-tert-Butylamino)-3',4'-dichloropropiophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chloroheptanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chlorohexanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chlorooctanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)-3'-chloropentanophenone | Drug Info | [530442] | |||
2-(N-tert-Butylamino)propiophenone | Drug Info | [530442] | |||
2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one | Drug Info | [530728] | |||
2-(tert-butylamino)-1-m-tolylpropan-1-one | Drug Info | [530728] | |||
2-(tert-butylamino)-1-p-tolylpropan-1-one | Drug Info | [530728] | |||
2-(tert-Butylamino)-3',4'-dichlorobutyrophenone | Drug Info | [530442] | |||
2-(tert-Butylamino)-3',4'-dichloropentanophenone | Drug Info | [530442] | |||
2-Amino-1-(4-methylthiophenyl)propane | Drug Info | [530347] | |||
2-Aminomethyl-5-(p-bromophenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(p-chlorophenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(p-t-butylphenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-Aminomethyl-5-(phenyl)tetrahydrofuran | Drug Info | [529955] | |||
2-phenoxy-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2pyrrolidin-1-yl-1-phenylpentan-1-one | Drug Info | [528036] | |||
3-(1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine | Drug Info | [529764] | |||
3-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile | Drug Info | [528224] | |||
3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol | Drug Info | [528224] | |||
3-(3'-furyl)-aniline | Drug Info | [528735] | |||
3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine | Drug Info | [530596] | |||
3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | Drug Info | [525906] | |||
3alpha-(bis-chloro-phenylmethoxy)tropane | Drug Info | [528473] | |||
4-((naphthalen-2-yloxy)methyl)piperidine | Drug Info | [530012] | |||
4-(1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine | Drug Info | [528760] | |||
4-(2-((3-fluorophenoxy)methyl)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(2-fluorobenzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-chlorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorobenzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorophenoxy)-4-methylphenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)-3-fluorophenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)-6-fluorophenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(phenoxymethyl)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine | Drug Info | [530596] | |||
4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(2-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(3'-furyl)-aniline | Drug Info | [528735] | |||
4-(3-fluoro-2-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one | Drug Info | [531079] | |||
6-(piperidin-4-ylmethoxy)-2-naphthonitrile | Drug Info | [530012] | |||
7-(piperidin-4-ylmethoxy)-2-naphthonitrile | Drug Info | [530012] | |||
8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane | Drug Info | [525906] | |||
Amfepramone | Drug Info | [536103] | |||
AMIFLAMINE | Drug Info | [533479] | |||
Amitifadine | Drug Info | [543974] | |||
Amitriptyline | Drug Info | [536774], [537983] | |||
Amoxapine | Drug Info | [537875] | |||
Atomoxetine | Drug Info | [536025], [536749] | |||
Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine | Drug Info | [529592] | |||
Bupropion | Drug Info | [537422] | |||
Bupropion+naltrexone | Drug Info | [536710] | |||
Cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine | Drug Info | [529530] | |||
Cocaine | Drug Info | [537241] | |||
D-166A | Drug Info | [529287] | |||
D-211A | Drug Info | [529287] | |||
D-211B | Drug Info | [529287] | |||
D-254C | Drug Info | [529287] | |||
D-257A | Drug Info | [529287] | |||
D-257C | Drug Info | [529287] | |||
Dasotraline | Drug Info | [533235] | |||
Desipramine | Drug Info | [537457] | |||
Desvenalfaxine succinate | Drug Info | [536647] | |||
Diethylpropion | Drug Info | [536130] | |||
DIFLUOROBENZTROPINE | Drug Info | [528473] | |||
DOV 21947 | Drug Info | [536580] | |||
DOV-216303 | Drug Info | [536580] | |||
Duloxetine | Drug Info | [536331], [537531] | |||
GSK-1360707 | Drug Info | [532361] | |||
GSK372475 | Drug Info | [536580] | |||
Hypericum | Drug Info | [534900] | |||
Imipramine | Drug Info | [534848], [536967] | |||
Iobenguane I 123 injection | Drug Info | [529941] | |||
Iobenguane I-123 | Drug Info | [543974] | |||
Isobutyl-(4-methyl-benzyl)-piperidin-4-yl-amine | Drug Info | [528048] | |||
KF-A5 | Drug Info | [529032] | |||
Maprotiline | Drug Info | [536083] | |||
MCT-125 | Drug Info | [543974] | |||
MDL-28618 | Drug Info | [529620] | |||
METHYLENEDIOXYAMPHETAMINE | Drug Info | [530914] | |||
METHYLENEDIOXYMETHAMPHETAMINE | Drug Info | [530347] | |||
Milnacipran | Drug Info | [537622] | |||
N,N-dimethyl(2-phenoxyphenyl)methanamine | Drug Info | [529278] | |||
N-(2-oxazolemethyl)milnacipran | Drug Info | [529263] | |||
N-benzyl-N-isobutylpiperidin-4-amine | Drug Info | [528048] | |||
N-desalkylquetiapine | Drug Info | [529198] | |||
NISOXETINE | Drug Info | [529670] | |||
norzotepine | Drug Info | [530783] | |||
NS 2359 | Drug Info | [536499] | |||
Para-chloroamphetamine | Drug Info | [530347] | |||
PF-18298 | Drug Info | [530918] | |||
PF-3409409 | Drug Info | [530265] | |||
PF-526014 | Drug Info | [530918] | |||
Phenmetrazine | Drug Info | [535503] | |||
Phentermine | Drug Info | [535068] | |||
POLYGALATENOSIDE B | Drug Info | [528443] | |||
Protriptyline | Drug Info | [537742] | |||
PTI-601 | Drug Info | [543974] | |||
PYROVALERONE | Drug Info | [528036] | |||
R-NORDULOXETINE | Drug Info | [530368] | |||
Radafaxine | Drug Info | [536122], [536295] | |||
Radaxafine HCl | Drug Info | [536374] | |||
Reboxetine | Drug Info | [535127] | |||
RG-7166 | Drug Info | [549028] | |||
RTI-219 | Drug Info | [528932] | |||
S-34324 | Drug Info | [527481] | |||
S33005 | Drug Info | [536286] | |||
SPD-473 | Drug Info | [527287] | |||
Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine | Drug Info | [529530] | |||
Trimipramine | Drug Info | [536168] | |||
Ultracet | Drug Info | [537457] | |||
Venlafaxine | Drug Info | [537422] | |||
WAY-256805 | Drug Info | [529536] | |||
WIN-35065-2 | Drug Info | [534240] | |||
WIN-35066-2 | Drug Info | [527309] | |||
WIN_35428 | Drug Info | [534240] | |||
XEN-2174 | Drug Info | [527387] | |||
[3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine | Drug Info | [527062] | |||
[3H]mazindol | Drug Info | [527164] | |||
[3H]nisoxetine | Drug Info | [543974] | |||
{2-[3-(Phenylsulfonyl)-1H-indol-4-yl]ethyl}amine | Drug Info | [530455] | |||
Enhancer | 18F-LMI-1195 | Drug Info | [532351] | ||
Modulator | 3,4-Methylenedioxymethamphetamine | Drug Info | [551382] | ||
Bicifadine | Drug Info | ||||
BL-1021 | Drug Info | ||||
Iobenguane I-123 - GE Healthcare | Drug Info | [529941] | |||
Levomilnacipran | Drug Info | [530677] | |||
Manifaxine | Drug Info | [527845] | |||
Mazindol | Drug Info | [556264] | |||
Metaiodobenzylguanidine I-131 | Drug Info | [532685] | |||
MMDA | Drug Info | [551393] | |||
Napitane mesilate | Drug Info | ||||
NS-2389 | Drug Info | [550007] | |||
R-sibutramine metabolite | Drug Info | ||||
Rhopressa | Drug Info | [533091] | |||
Roclatan | Drug Info | [1572591] | |||
Sibutramine | Drug Info | [556264] | |||
Suronacrine maleate | Drug Info | ||||
Tapentadol hydrochloride | Drug Info | [529941] | |||
TD-9855 | Drug Info | [533083] | |||
Blocker | Esreboxetine | Drug Info | [549974] | ||
Activator | NSD-644 | Drug Info | [551423] | ||
Agonist | TQ-1017 | Drug Info | [551871] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
References | |||||
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Ref 546575 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009012) | ||||
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Ref 530347 | Eur J Med Chem. 2009 Dec;44(12):4862-88. Epub 2009 Aug 6.Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. | ||||
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Ref 530783 | Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J Pharmacol Exp Ther. 2010 Jun;333(3):772-81. | ||||
Ref 530914 | Bioorg Med Chem. 2010 Jun 1;18(11):4009-31. Epub 2010 Apr 13.Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines. | ||||
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Ref 530946 | J Med Chem. 2010 Jun 24;53(12):4731-48.Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. | ||||
Ref 531079 | J Med Chem. 2010 Sep 9;53(17):6386-97.Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. | ||||
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Ref 532351 | Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts. J Nucl Med. 2013 Jul;54(7):1142-6. | ||||
Ref 532361 | Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. | ||||
Ref 532685 | Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res. 2014 Apr 15;20(8):2182-91. | ||||
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Ref 533091 | Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4. | ||||
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Ref 534240 | J Med Chem. 1996 Oct 11;39(21):4139-41.3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter. | ||||
Ref 534848 | Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999 Mar 5;368(2-3):277-83. | ||||
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