Drug Information

Drug General Information
Drug ID
D01JYY
Former ID
DNC010176
Drug Name
(R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530367]
Structure
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2D MOL

3D MOL
Formula
C19H24N2O
Canonical SMILES
CC(C)CN(C1CCNC1)C(=O)C2=CC3=CC=CC=C3C=C2
InChI
1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m1/s1
InChIKey
CEUJKSVEPJAVKD-GOSISDBHSA-N
PubChem Compound ID
11323940
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [530367]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [530367]
Sodium-dependent dopamine transporter Target Info Inhibitor [530367]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [530367]
KEGG Pathway Serotonergic synapsehsa04728:Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channelsR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium ChannelsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
References
Ref 530367Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.
Ref 530367Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.

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