Drug Information

Drug General Information
Drug ID
D06PJD
Former ID
DNC009356
Drug Name
3-(1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529764]
Structure
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2D MOL

3D MOL
Formula
C18H20N2
Canonical SMILES
CNCCC(C1=CC=CC=C1)N2C=CC3=CC=CC=C32
InChI
1S/C18H20N2/c1-19-13-11-18(15-7-3-2-4-8-15)20-14-12-16-9-5-6-10-17(16)20/h2-10,12,14,18-19H,11,13H2,1H3
InChIKey
VDFAJYFMKVKZLC-UHFFFAOYSA-N
PubChem Compound ID
44593439
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [529764]
Sodium-dependent serotonin transporter Target Info Inhibitor [529764]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 529764Bioorg Med Chem Lett. 2008 Dec 1;18(23):6067-70. Epub 2008 Oct 11.Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.
Ref 529764Bioorg Med Chem Lett. 2008 Dec 1;18(23):6067-70. Epub 2008 Oct 11.Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.

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