Drug General Information
Drug ID	D0XY9E
Former ID	DNC010129
Drug Name	2-(N-tert-Butylamino)-3'-chloropentanophenone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530442]
Structure		Download 2D MOL 3D MOL
Formula	C15H22ClNO
Canonical SMILES	CCCC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C
InChI	1S/C15H22ClNO/c1-5-7-13(17-15(2,3)4)14(18)11-8-6-9-12(16)10-11/h6,8-10,13,17H,5,7H2,1-4H3
InChIKey	PREYWAJYVTVVPE-UHFFFAOYSA-N
PubChem Compound ID	3029724
Target and Pathway
Target(s)	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[530442]
	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[530442]
KEGG Pathway	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
References
Ref 530442	J Med Chem. 2009 Nov 12;52(21):6768-81.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.
Ref 530442	J Med Chem. 2009 Nov 12;52(21):6768-81.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.

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