Drug Information

Drug General Information
Drug ID
D0M4AQ
Former ID
DNC013428
Drug Name
2-((2-iodophenoxy)(phenyl)methyl)morpholine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528517]
Structure
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2D MOL

3D MOL
Formula
C17H18INO2
Canonical SMILES
C1COC(CN1)C(C2=CC=CC=C2)OC3=CC=CC=C3I
InChI
1S/C17H18INO2/c18-14-8-4-5-9-15(14)21-17(13-6-2-1-3-7-13)16-12-19-10-11-20-16/h1-9,16-17,19H,10-12H2
InChIKey
BHMLFPOTZYRDKA-UHFFFAOYSA-N
PubChem Compound ID
44438550
Target and Pathway
Target(s) Sodium-dependent dopamine transporter Target Info Inhibitor [528517]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [528517]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
References
Ref 528517Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. Epub 2006 Oct 12.Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.
Ref 528517Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. Epub 2006 Oct 12.Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.

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