| Drug General Information |
| Drug ID |
D0M1OE
|
| Former ID |
DNC013483
|
| Drug Name |
ANOLOBINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H15NO3
|
| Canonical SMILES |
C1CNC2CC3=C(C=CC(=C3)O)C4=C2C1=CC5=C4OCO5
|
| InChI |
1S/C17H15NO3/c19-11-1-2-12-10(5-11)6-13-15-9(3-4-18-13)7-14-17(16(12)15)21-8-20-14/h1-2,5,7,13,18-19H,3-4,6,8H2/t13-/m1/s1
|
| InChIKey |
LTSPCGWFQLHECP-CYBMUJFWSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[2]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Alcoholismhsa04015:Rap1 signaling pathway
|
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
|
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Gap junction
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Alcoholism
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PANTHER Pathway
|
Adrenaline and noradrenaline biosynthesis
|
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Parkinson disease
|
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Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
|
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Pathway Interaction Database
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Alpha-synuclein signaling
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
|
Monoamine Transport
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NRF2 pathway
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Dopaminergic Neurogenesis
|
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
|
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Neurotransmitter Clearance In The Synaptic CleftWP666:Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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| References |
| REF 1 | J Med Chem. 2007 Jan 25;50(2):171-81.Advances in development of dopaminergic aporphinoids. |
|---|
| REF 2 | Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. |
|---|
