Drug General Information |
Drug ID |
D0M1OE
|
Former ID |
DNC013483
|
Drug Name |
ANOLOBINE
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C17H15NO3
|
Canonical SMILES |
C1CNC2CC3=C(C=CC(=C3)O)C4=C2C1=CC5=C4OCO5
|
InChI |
1S/C17H15NO3/c19-11-1-2-12-10(5-11)6-13-15-9(3-4-18-13)7-14-17(16(12)15)21-8-20-14/h1-2,5,7,13,18-19H,3-4,6,8H2/t13-/m1/s1
|
InChIKey |
LTSPCGWFQLHECP-CYBMUJFWSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[2]
|
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Dopaminergic synapse
|
Parkinson's disease
|
Cocaine addiction
|
Amphetamine addiction
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Alcoholismhsa04015:Rap1 signaling pathway
|
cAMP signaling pathway
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Neuroactive ligand-receptor interaction
|
Gap junction
|
Alcoholism
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesis
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Parkinson disease
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Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
|
Nicotine pharmacodynamics pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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Reactome
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Na+/Cl- dependent neurotransmitter transportersR-HSA-390651:Dopamine receptors
|
G alpha (i) signalling events
|
WikiPathways
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Monoamine Transport
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NRF2 pathway
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Dopaminergic Neurogenesis
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
|
Neurotransmitter Clearance In The Synaptic CleftWP666:Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
|
GPCR ligand binding
|
GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
|
References |
REF 1 | J Med Chem. 2007 Jan 25;50(2):171-81.Advances in development of dopaminergic aporphinoids. |
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REF 2 | Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. |