Target Information

Target General Infomation
Target ID
T67162
Former ID
TTDS00012
Target Name
D(2) dopamine receptor
Gene Name
DRD2
Synonyms
Dopamine D2 receptor; Dopamine receptor 2; DRD2
Target Type
Successful
Disease Alcohol use disorders [ICD9: 303; ICD10: F10.2]
Allergy [ICD9: 995.3; ICD10: T78.4]
Asthma; Bronchitis [ICD9: 466, 490, 491, 493; ICD10: J20-J21, J42, J45]
Alzheimer disease [ICD9: 331; ICD10: G30]
Advanced stage Parkinson's disease [ICD9: 332; ICD10: F02.3, G20]
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Bipolar disorder [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10: F31, F40-F42]
Bipolar disorder; Schizophrenia [ICD9:296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300, 295; ICD10: F31, F40-F42, F20]
Breast cancer [ICD9: 174, 175; ICD10: C50]
Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Cardiac failure [ICD10: I50]
Cardiotonic [ICD10: I50]
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63]
Carcinoid syndrome; Acromegaly [ICD9:253; ICD10: E34.0, E22.0]
Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10: J40-J44, J47]
Corneal vascularity; Hyperaemia; Itching [ICD10: L29]
Depressive fatigue [ICD9: 780.71; ICD10: R53.82]
Dermal necrosis [ICD10: K05]
Emesis [ICD9: 787; ICD10: R11]
Fibrosis [ICD9: 709.2; ICD10: L90.5]
False perceptions; Bipolar disorder [ICD9:297, 780.1, 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10: F22, R44, F31, F40-F42]
Gastrointestinal problems [ICD9: 536, 750; ICD10: K30-K31, Q40-Q41]
Glaucoma [ICD9: 365; ICD10: H40-H42]
Hypotension [ICD9: 458, 796.3; ICD10: I95]
Hypertension [ICD9: 401; ICD10: I10-I16]
Hyperprolactinemia [ICD9: 253.1; ICD10: E22.1]
Heart failure [ICD9: 428; ICD10: I50]
Hypertension; Angina pectoris [ICD9:401, 413; ICD10: I10-I16, I20]
Huntington's disease [ICD9: 294.1, 333.4; ICD10: F02.2, G10]
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25]
Inflammatory bowel disease [ICD9: 555, 556; ICD10: K50, K51]
Idiopathic thrombocytopenic purpura [ICD9: 287.31; ICD10: D69.3]
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0]
Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension [ICD10: N40, C61]
Migraine headaches [ICD9: 346; ICD10: G43]
Maintain blood pressure in hypotensive states [ICD10: I10]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Nasal congestion [ICD9: 478.19; ICD10: J34.89]
Non-small cell lung cancer [ICD10: C33-C34]
Nausea; Vomiting [ICD9: 787, 787.0; ICD10: R11]
Ophthalmic disease [ICD10: H00-H59]
Peripheral vasoconstriction; Pulmonary hypertension [ICD9:443, 416; ICD10: I73, I27.0, I27.2]
Postpartum haemorrhage [ICD9: 666; ICD10: O72]
Psychosis [ICD10: F20-F29]
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29]
Pain; Inflammatory diseases [ICD9: 338,780; ICD10: R52, G89]
Parkinson's disease; Restless legs syndrome [ICD9: 332, 333.94; ICD10: F02.3, G20, G25.8]
Parkinson's disease [ICD9: 332; ICD10: G20]
Psychiatric disorder [ICD9: 290-319; ICD10: F01-F99]
Schizophrenia; Bipolar disorder [ICD9: 295, 296; ICD10: F20, F31]
Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10: F20, F25]
Substance dependence [ICD10: F10-F19]
Schizoaffective disorder; Schizophrenia [ICD9: 295, 295.70; ICD10: F20, F25]
Sexual dysfunction [ICD9: 302.7; ICD10: F52]
Schizophrenia [ICD9: 295; ICD10: F20]
Function
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
BioChemical Class
GPCR rhodopsin
Target Validation
T67162
UniProt ID
P14416
Sequence
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
Structure
1I15; 2YOU
Drugs and Mode of Action
Drug(s) Acetophenazine Drug Info Approved False perceptions; Bipolar disorder [1], [2]
Amisulpride Drug Info Approved Schizophrenia [3], [4]
Aniracetam Drug Info Approved Cerebrovascular ischaemia [5], [6]
Apomorphine Drug Info Approved Parkinson's disease [7], [8]
Aripiprazole Drug Info Approved Schizophrenia [9], [10]
Bevantolol Drug Info Approved Hypertension; Angina pectoris [3], [2]
Bromocriptine Drug Info Approved Parkinson's disease [11], [12]
Cabergoline Drug Info Approved Hyperprolactinemia [11], [13]
Cariprazine Drug Info Approved Bipolar disorder [14], [15]
Carphenazine Drug Info Approved Insomnia [2]
Chlorpromazine Drug Info Approved Schizophrenia [16], [17]
Chlorprothixene Drug Info Approved Psychotic disorders [18]
Dapiprazole Drug Info Approved Glaucoma [2]
Denopamine Drug Info Approved Cardiotonic [19], [2]
Dihydroergotamine Drug Info Approved Migraine headaches [20], [21]
Dihydroergotoxine Drug Info Approved Alzheimer disease [22]
Docarpamine Drug Info Approved Hypertension [2]
Domperidone Drug Info Approved Gastrointestinal problems [23], [24]
Dopamine Drug Info Approved Parkinson's disease [25], [26]
Dopexamine Drug Info Approved Cardiac failure [2]
Droperidol Drug Info Approved Nausea; Vomiting [27], [28]
Ephedrine Drug Info Approved Asthma; Bronchitis [29], [30]
Ergonovine Drug Info Approved Postpartum haemorrhage [31], [32]
Fluspirilene Drug Info Approved Schizophrenia [33], [34]
Haloperidol Drug Info Approved Schizophrenia [3], [35]
Ibopamine hci Drug Info Approved Cardiotonic [2]
Iloperidone Drug Info Approved Schizophrenia [36], [37]
Levodopa Drug Info Approved Parkinson's disease [38]
Levomepromazine Drug Info Approved Psychosis [2]
Lisuride Drug Info Approved Parkinson's disease [39], [40]
Loxapine Drug Info Approved Schizophrenia [2]
Lurasidone hydrochloride Drug Info Approved Schizophrenia [41], [42], [43], [2]
Mephentermine Drug Info Approved Maintain blood pressure in hypotensive states [2]
Mesoridazine Drug Info Approved Schizophrenia [44], [45]
Metaraminol Drug Info Approved Hypotension [46], [47]
Methamfetamine Drug Info Approved Pain; Inflammatory diseases [48]
Methyldopa Drug Info Approved Hypertension [49], [50]
Metoclopramide Drug Info Approved Nausea; Vomiting [51], [52]
Molindone Drug Info Approved Schizophrenia [53], [54]
N-0923 Drug Info Approved Parkinson's disease [55], [56]
Naphazoline Drug Info Approved Corneal vascularity; Hyperaemia; Itching [2]
Nemonapride Drug Info Approved Schizophrenia [25], [57]
Olanzapine Drug Info Approved Schizophrenia [58], [59]
OPC-34712 Drug Info Approved Major depressive disorder [60], [61]
PD-172760 Drug Info Approved Schizophrenia [25]
Perazine Drug Info Approved Psychotic disorders [2]
Pergolide Drug Info Approved Parkinson's disease [62], [11]
Perphenazine Drug Info Approved Schizophrenia; Bipolar disorder [63], [64]
Phenoxybenzamine Drug Info Approved Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension [2]
Phentolamine Drug Info Approved Dermal necrosis [65], [66]
Phenylephrine Drug Info Approved Ophthalmic disease [67], [68]
Phenyltoloxamine Drug Info Approved Allergy [2]
Pimozide Drug Info Approved Schizophrenia [69], [70]
Piperacetazine Drug Info Approved Schizophrenia [2]
Pramipexole Drug Info Approved Parkinson's disease [71], [72]
Prochlorperazine Drug Info Approved Nausea; Vomiting [73], [74]
Pseudoephedrine Drug Info Approved Nasal congestion [75], [76]
Quetiapine Drug Info Approved Schizophrenia [77], [78]
Quinagolide Drug Info Approved Hyperprolactinemia [3]
Risperidone Drug Info Approved Schizophrenia [79], [80]
Ropinirole Drug Info Approved Parkinson's disease [81], [82]
Sulpiride Drug Info Approved Schizophrenia [83], [84]
Thiethylperazine Drug Info Approved Nausea; Vomiting [85], [86]
Thioridazine Drug Info Approved Schizophrenia [87], [88]
Thiothixene Drug Info Approved Schizophrenia [89], [90]
Tiapride Drug Info Approved Alcohol use disorders [2]
Tolazoline Drug Info Approved Peripheral vasoconstriction; Pulmonary hypertension [91], [92], [2]
Ziprasidone Drug Info Approved Schizophrenia [79], [93]
Zuclopenthixol Drug Info Approved Schizophrenia [94], [95]
Raclopride Drug Info Phase 4 Psychotic disorders [96], [97]
Talipexole Drug Info Phase 4 Discovery agent [98], [99]
Bis(olanzapine) pamoate monohydrate Drug Info Phase 3 Psychotic disorders [2]
Blonanserin Drug Info Phase 3 Schizophrenia [25], [100]
CQA 206-291 Drug Info Phase 3 Parkinson's disease [101]
Entacapone+levodopa+carbidopa Drug Info Phase 3 Parkinson's disease; Restless legs syndrome [102]
Lisuride Drug Info Phase 3 Fibrosis [103]
Pridopidine Drug Info Phase 3 Huntington's disease [104]
RBP-7000 Drug Info Phase 3 Non-small cell lung cancer [105]
Sumanirole Drug Info Phase 3 Parkinson's disease [106], [107]
Zicronapine Drug Info Phase 3 Schizophrenia [108]
P2B-001 Drug Info Phase 2/3 Parkinson's disease [109]
APD-403 Drug Info Phase 2 Emesis [110]
Aplindore fumarate Drug Info Phase 2 Schizophrenia [25]
BIM23A760 Drug Info Phase 2 Carcinoid syndrome; Acromegaly [111], [112]
BL-1020 Drug Info Phase 2 Schizophrenia [25]
CGS-15873A Drug Info Phase 2 Psychotic disorders [113]
CLR-3001 Drug Info Phase 2 Major depressive disorder [114]
Intranasal apomorphine Drug Info Phase 2 Sexual dysfunction [115]
JNJ-37822681 Drug Info Phase 2 Schizophrenia [116]
Mazapertine succinate Drug Info Phase 2 Psychotic disorders [117]
Ocaperidone Drug Info Phase 2 Schizophrenia; Schizoaffective disorders [118], [119], [25]
Pardoprunox Drug Info Phase 2 Advanced stage Parkinson's disease [71]
PD-143188 Drug Info Phase 2 Psychotic disorders [120]
ROXINDOLE Drug Info Phase 2 Psychotic disorders [121], [122]
RP5063 Drug Info Phase 2 Schizoaffective disorder; Schizophrenia [123]
SDZ-MAR-327 Drug Info Phase 2 Psychotic disorders [124], [25]
XP-21279 Drug Info Phase 2 Parkinson's disease [125]
(-)-3PPP, Maryland Drug Info Phase 1 Schizophrenia [126]
1192U90 Drug Info Phase 1 Psychotic disorders [127]
Abaperidone Drug Info Phase 1 Schizophrenia [128]
Carmoxirole Drug Info Phase 1 Hypertension [129]
Dopamine Drug Info Phase 1 Hypotension [26], [2]
Lu-02-750 Drug Info Phase 1 Parkinson's disease [130]
Lu-AE04621 Drug Info Phase 1 Parkinson's disease [131]
SKL-10406 Drug Info Phase 1 Major depressive disorder [132]
SSR-181507 Drug Info Phase 1 Schizophrenia [25]
Umespirone Drug Info Phase 1 Anxiety disorder [133]
YKP-1358 Drug Info Phase 1 Schizophrenia; Schizoaffective disorders [25]
D1 agonist D2 antagonist Drug Info Preclinical Schizophrenia [25]
F-15063 Drug Info Preclinical Schizophrenia [134]
Org-23366 Drug Info Preclinical Schizophrenia [25]
PD-157695 Drug Info Preclinical Schizophrenia [25]
PD-158771 Drug Info Preclinical Schizophrenia [25]
PGX-200097 Drug Info Preclinical Schizophrenia [135]
S32504 Drug Info Preclinical Parkinson's disease [136]
Carphenazine Drug Info Withdrawn from market Schizophrenia [137], [138]
Fencamfamine Drug Info Withdrawn from market Depressive fatigue [139]
Flupenthixol Drug Info Withdrawn from market Schizophrenia [140], [141]
Nomifensine Drug Info Withdrawn from market Breast cancer [142], [2]
Remoxipride Drug Info Withdrawn from market Schizophrenia [143]
Sertindole Drug Info Withdrawn from market Schizophrenia [144], [145]
(S)-amisulpride Drug Info Discontinued in Phase 4 Schizophrenia [25]
Bifeprunox Drug Info Discontinued in Phase 3 Schizophrenia [25]
Lamectacin Drug Info Discontinued in Phase 3 Bacterial infections [146]
NOLOMIROLE HYDROCHLORIDE Drug Info Discontinued in Phase 3 Heart failure [147]
Sibenadet Drug Info Discontinued in Phase 3 Chronic obstructive pulmonary disease [148]
TIOSPIRONE Drug Info Discontinued in Phase 3 Discovery agent [149], [150]
ATI-9242 Drug Info Discontinued in Phase 2 Schizophrenia [151]
BAM-1110 Drug Info Discontinued in Phase 2 Parkinson's disease [152]
Declopramide Drug Info Discontinued in Phase 2 Inflammatory bowel disease [153]
FOSOPAMINE Drug Info Discontinued in Phase 2 Hypertension [154]
MAZAPERTINE Drug Info Discontinued in Phase 2 Discovery agent [155]
Naxagolide Drug Info Discontinued in Phase 2 Parkinson's disease [156]
PF-217830 Drug Info Discontinued in Phase 2 Bipolar disorder; Schizophrenia [157]
Romergoline Drug Info Discontinued in Phase 2 Anxiety disorder [158]
Sarizotan Drug Info Discontinued in Phase 2 Parkinson's disease [106]
SAVOXEPIN MESYLATE Drug Info Discontinued in Phase 2 Psychotic disorders [159]
SLV-310 Drug Info Discontinued in Phase 2 Schizophrenia [25]
AM-831 Drug Info Discontinued in Phase 1 Schizophrenia [160]
DU-29894 Drug Info Discontinued in Phase 1 Psychotic disorders [161]
Ordopidine Drug Info Discontinued in Phase 1 Psychotic disorders [162]
S-18327 Drug Info Discontinued in Phase 1 Psychotic disorders [163]
SDZ-GLC-756 Drug Info Discontinued in Phase 1 Glaucoma [164]
SLV-313 Drug Info Discontinued in Phase 1 Schizophrenia [25]
1192U90 Drug Info Terminated Schizophrenia [25]
A-80426 Drug Info Terminated Discovery agent [165]
AMR-103 Drug Info Terminated Parkinson's disease [166]
BIMG80 Drug Info Terminated Psychotic disorders [167]
CGP-25454A Drug Info Terminated Major depressive disorder [168]
CP-903397 Drug Info Terminated Schizophrenia [169]
E-2040 Drug Info Terminated Schizophrenia [170]
Etrabamine Drug Info Terminated Parkinson's disease [171]
GMC-283 Drug Info Terminated Schizophrenia [25]
HMR-2934 Drug Info Terminated Schizophrenia [25]
LY-243062 Drug Info Terminated Inflammatory disease [172]
NGD-93-1 Drug Info Terminated Psychotic disorders [173]
NNC-22-0031 Drug Info Terminated Psychotic disorders [174]
Org-10490 Drug Info Terminated Psychotic disorders [175]
PD-128483 Drug Info Terminated Discovery agent [176]
PNU-96391A Drug Info Terminated Substance dependence [177]
RWJ-25730 Drug Info Terminated Psychotic disorders [178]
S32504 Drug Info Terminated Major depressive disorder [179]
SDZ-MAR-327 Drug Info Terminated Schizophrenia [25]
SLV-307 Drug Info Terminated Parkinson's disease [180]
Y-20024 Drug Info Terminated Psychotic disorders [181]
Y-931 Drug Info Terminated Schizophrenia [25]
ZD-3638 Drug Info Terminated Schizophrenia [25]
Inhibitor (+)-(1R,1'S)-berbamunine hydrochloride Drug Info [182]
(+)-(1R,1'S)-thaligrisine hydrochloride Drug Info [182]
(+)-3-(1-Propyl-piperidin-3-yl)-phenol Drug Info [183]
(+)-BUTACLAMOL Drug Info [184]
(+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin Drug Info [185]
(+/-)-nantenine Drug Info [186]
(-)-(1S,1'R)-O,O-dimethylgrisbine hydrochloride Drug Info [182]
(-)-3-(1-Propyl-piperidin-3-yl)-benzonitrile Drug Info [187]
(-)-5-hydroxy-2-(dipropylamino)tetralin Drug Info [188]
(4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine Drug Info [189]
(4-Quinolin-2-ylpiperazin-1-yl)acetic Acid Drug Info [190]
(5-Methoxy-chroman-3-yl)-dipropyl-amine Drug Info [191]
(R)-(+)-coclaurine Drug Info [192]
(R)-(-)-10-methyl-11-hydroxyaporphine Drug Info [193]
(R)-(-)-11-hydroxy-N-n-propylnoraporphine Drug Info [194]
(R)-(-)-2-methoxy-11-hydroxyaporphine Drug Info [194]
(R)-(-)-2-methoxy-N-npropylnorapomorphine Drug Info [194]
(R)-(-)-2-Methyl-apomorphine hydrochloride Drug Info [195]
(R)-(-)-2-Phenyl-apomorphine hydrochloride Drug Info [195]
(R)-(-)-N-ethyl-2-methoxy-11-hydroxynoraporphine Drug Info [194]
(R)-(-)-N-propyl-2-methoxy-11-hydroxynoraporphine Drug Info [194]
(S)-BULBOCAPNINE Drug Info [196]
(S)-secoantioquine hydrochloride Drug Info [182]
(S)APOMORPHINE Drug Info [197]
(S,R)-antioquine hydrochloride Drug Info [182]
(S,R)-isotetrandrine hydrochloride Drug Info [182]
(S,R)-pseudoxandrine hydrochloride Drug Info [182]
(S,S)-oxandrine hydrochloride Drug Info [182]
1,2,3,7,12,12a-hexahydro-1-aza-pleiadene-5,6-diol Drug Info [196]
1,2-Bis-[R-(-)-apomorphine-2'-oxy]ethane Drug Info [198]
1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane Drug Info [199]
1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane Drug Info [199]
1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane Drug Info [199]
1,6-bis(4-m-tolylpiperazin-1-yl)hexane Drug Info [199]
1,6-bis(4-phenylpiperazin-1-yl)hexane Drug Info [199]
1-(3-Hydroxyphenyl)-4-propylpiperazine Drug Info [200]
1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine Drug Info [201]
1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one Drug Info [202]
1-(benzyloxy)-2-(2-phenylethyl)benzene Drug Info [203]
1-(benzyloxy)-2-[2-(3-methoxyphenyl)ethyl]benzene Drug Info [203]
1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol Drug Info [204]
1-Aminomethyl-isochroman-5,6-diol Drug Info [205]
1-Benzyl-4-(2-ethynyl-pyrrol-1-yl)-piperidine Drug Info [206]
1-Benzyl-4-(2-iodo-pyrrol-1-yl)-piperidine Drug Info [206]
1-Benzyl-4-(2-oxazol-5-yl-pyrrol-1-yl)-piperidine Drug Info [206]
1-Benzyl-4-(3-hydroxyphenyl)piperidine Drug Info [200]
1-Benzyl-4-(3-oxazol-5-yl-pyrrol-1-yl)-piperidine Drug Info [206]
1-Benzyl-4-pyrrol-1-yl-piperidine Drug Info [206]
1-Benzyl-4-[3-(methylsulfonyl)phenyl]piperazine Drug Info [200]
1-Benzyl-4-[3-(methylsulfonyl)phenyl]piperidine Drug Info [200]
1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine Drug Info [207]
1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol Drug Info [208]
1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine Drug Info [209]
1-Propyl-3-m-tolyl-piperidine hydrochloride Drug Info [210]
1-Propyl-3-o-tolyl-piperidine hydrochloride Drug Info [210]
1-Propyl-3-p-tolyl-piperidine hydrochloride Drug Info [210]
1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene Drug Info [203]
1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine Drug Info [211]
1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine Drug Info [211]
1-[3-(Methylsulfonyl)phenyl]-4-propylpiperazine Drug Info [200]
2,3-Dihydro-1H-indol-5-ol Drug Info [208]
2-(4-Dipropylamino-cyclohexylidene)-malononitrile Drug Info [189]
2-methoxyapomorphine Drug Info [198]
2-Methyl-8-phenyl-1,2,3,4-tetrahydro-isoquinoline Drug Info [212]
2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine Drug Info [203]
2-{[R-(-)-Apomorphine-2'-oxy]ethoxy}-ethanol Drug Info [198]
3,8-dibromoboldine Drug Info [213]
3-(1-Propyl-pyrrolidin-3-yl)-phenol Drug Info [209]
3-(2,3-Dimethyl-phenyl)-1-propyl-piperidine Drug Info [214]
3-(2,3-Dimethyl-phenyl)-piperidine Drug Info [214]
3-(2,4-Dimethyl-phenyl)-1-propyl-piperidine Drug Info [214]
3-(2,5-Dimethyl-phenyl)-1-propyl-piperidine Drug Info [214]
3-(2,6-Dimethyl-phenyl)-1-propyl-piperidine Drug Info [214]
3-(2-Benzylamino-ethoxy)-phenol Drug Info [215]
3-(3,4-Dimethyl-phenyl)-1-propyl-piperidine Drug Info [214]
3-(3,4-Dimethyl-phenyl)-piperidine Drug Info [214]
3-(3,5-Dimethyl-phenyl)-1-propyl-piperidine Drug Info [214]
3-(3,5-Dimethyl-phenyl)-piperidine Drug Info [214]
3-(4-Benzyl-piperazin-1-yl)-phenol Drug Info [216]
3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one Drug Info [184]
3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole Drug Info [217]
3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole Drug Info [217]
3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole Drug Info [217]
3-(N-propylpiperidin-4-yl)phenol Drug Info [200]
3-(Octahydro-indolizin-8-yl)-phenol Drug Info [218]
3-(Octahydro-quinolizin-1-yl)-phenol Drug Info [218]
3-(Octahydro-quinolizin-3-yl)-phenol Drug Info [218]
3-bromoboldine Drug Info [213]
3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol Drug Info [219]
3-Chloroboldine Drug Info [213]
3-Cyclohexyl-1-propyl-piperidine hydrochloride Drug Info [210]
3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol Drug Info [219]
3-Iodoboldine Drug Info [213]
3-Naphthalen-1-yl-1-propyl-pyrrolidine Drug Info [209]
3-Naphthalen-1-yl-pyrrolidine Drug Info [209]
3-Phenyl-1-propyl-piperidine hydrochloride Drug Info [210]
3-Phenyl-1-propyl-pyrrolidine Drug Info [209]
3-Phenyl-pyrrolidine Drug Info [209]
3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine Drug Info [203]
4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one Drug Info [215]
4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole Drug Info [216]
4-(4-Benzyl-piperazin-1-yl)-1H-indole Drug Info [216]
4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole Drug Info [216]
4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole Drug Info [216]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info [220]
4-Benzyl-1-chroman-2-ylmethyl-piperidine Drug Info [184]
4-Benzyl-1-chroman-3-ylmethyl-piperidine Drug Info [184]
4-Benzyl-1-indan-2-ylmethyl-piperidine Drug Info [184]
4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Drug Info [200]
7-(2-Amino-ethyl)-4-hydroxy-3H-benzothiazol-2-one Drug Info [221]
7-(2-Dipropylamino-ethyl)-3H-benzothiazol-2-one Drug Info [221]
A-690344 Drug Info [222]
A-70108 Drug Info [205]
A-706149 Drug Info [223]
A-80426 Drug Info [224]
Aniracetam Drug Info [225]
ANOLOBINE Drug Info [196]
ANONAINE Drug Info [196]
Azaperone Drug Info [226]
Benzyl-[2-(1H-indazol-4-yloxy)-ethyl]-amine Drug Info [215]
Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine Drug Info [215]
Bis-{[R-(-)-apomorphine-2-oxy]ethyl} ether Drug Info [198]
BOLDINE Drug Info [213]
BRL-25594 Drug Info [227]
BRL-26175 Drug Info [228]
CLEBOPRIDE Drug Info [227]
D-189 Drug Info [229]
D-190 Drug Info [229]
D-192 Drug Info [229]
D-193 Drug Info [229]
D-203 Drug Info [229]
D-210 Drug Info [229]
D-218 Drug Info [229]
D-219 Drug Info [229]
D-220 Drug Info [229]
D-237 Drug Info [185]
D-264 Drug Info [230]
D-315 Drug Info [231]
D-366 Drug Info [188]
EPIDEPRIDE Drug Info [232]
Ethyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine Drug Info [233]
ETICLOPRIDE Drug Info [234]
Etoloxamine Drug Info [211]
FLUANISONE Drug Info [235]
FLUMEZAPINE Drug Info [236]
FLUTROLINE Drug Info [237]
GLAUCINE Drug Info [196]
IBZM Drug Info [232]
IODOPRIDE Drug Info [232]
IODOSULPIRIDE Drug Info [232]
ISOCLOZAPINE Drug Info [238]
ISOLOXAPINE Drug Info [239]
L-741626 Drug Info [240]
MAZAPERTINE Drug Info [241]
MCL-515 Drug Info [242]
MCL-516 Drug Info [242]
N-(4-Dipropylaminobutyl)-4-biphenylcarboxamide Drug Info [243]
N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide Drug Info [244]
N-Ethyl-2-methylnorapomorphine hydrochloride Drug Info [245]
N-Ethyl-2-phenylnorapomorphine hydrochloride Drug Info [245]
N-METHYLSPIPERONE Drug Info [246]
N-Propyl-2-methylnorapomorphine hydrochloride Drug Info [245]
N-Propyl-2-phenylnorapomorphine hydrochloride Drug Info [245]
NOR-ROEFRACTINE Drug Info [192]
OCTOCLOTHEPIN Drug Info [247]
P2B-001 Drug Info [248]
PD-128483 Drug Info [249]
PD-135111 Drug Info [249]
PD-135146 Drug Info [249]
PD-135188 Drug Info [249]
PD-135222 Drug Info [249]
PD-135385 Drug Info [249]
PD-135478 Drug Info [249]
PD-135540 Drug Info [249]
PD-137789 Drug Info [249]
PD-137821 Drug Info [249]
PD-168077 Drug Info [210]
PD-172938 Drug Info [250]
PD-172939 Drug Info [250]
PG-01037 Drug Info [251]
PGX-200097 Drug Info [252]
Phenyltoloxamine Drug Info [211]
Preclamol Drug Info [218]
Propyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine Drug Info [233]
PUKATEINE Drug Info [196]
QUINPIROLE Drug Info [214]
R-N-PROPYLNORAPOMORPHINE Drug Info [194]
Ro-21-7767 Drug Info [253]
Rolicyclidine Drug Info [254]
ROXINDOLE Drug Info [255]
SB-258719 Drug Info [256]
SB-271046 Drug Info [257]
SCH-24518 Drug Info [258]
SK&F-89626 Drug Info [259]
SKF-89124A Drug Info [221]
SLV-314 Drug Info [260]
SNAP-94847 Drug Info [261]
SPIPERONE Drug Info [184]
STEPHOLIDINE Drug Info [262]
TIOSPIRONE Drug Info [263]
UH-232 Drug Info [264]
UH-301 Drug Info [265]
WAY-208466 Drug Info [266]
[2-(1H-Benzoimidazol-4-yloxy)-ethyl]-benzyl-amine Drug Info [215]
[R-(-)-Apomorphine-2-yl]-(2'-hydroxy-ethyl)ether Drug Info [198]
Antagonist (+)-S-14297 Drug Info [267]
(S)-amisulpride Drug Info [25]
1192U90 Drug Info [25]
Acetophenazine Drug Info [268], [269]
Amisulpride Drug Info [268], [270], [271]
Anti-D Drug Info [272]
APD-403 Drug Info [273]
Bevantolol Drug Info [274], [275]
BL-1020 Drug Info [25]
Blonanserin Drug Info [25]
Carphenazine Drug Info [268], [276]
Chlorpromazine Drug Info [277], [278], [279]
Chlorprothixene Drug Info [280]
CLR-151 Drug Info [273]
D1 agonist D2 antagonist Drug Info [25]
Dapiprazole Drug Info [281]
Domperidone Drug Info [282], [283]
Flupenthixol Drug Info [268], [284]
Fluspirilene Drug Info [285]
GMC-283 Drug Info [25]
Haloperidol Drug Info [268], [286]
HMR-2934 Drug Info [25]
Iloperidone Drug Info [36], [25]
Lamectacin Drug Info [287], [78]
Loxapine Drug Info [288]
Metoclopramide Drug Info [289], [283]
ML321 Drug Info [290]
nafadotride Drug Info [291]
Nomifensine Drug Info [292], [293]
Org-23366 Drug Info [25]
PD-157695 Drug Info [25]
PD-158771 Drug Info [25]
PD-172760 Drug Info [25]
Perphenazine Drug Info [294], [295]
Phenoxybenzamine Drug Info [296]
Phentolamine Drug Info [297]
Pimozide Drug Info [268], [298]
Prochlorperazine Drug Info [299], [300]
Raclopride Drug Info [301]
Remoxipride Drug Info [268], [288]
Risperidone Drug Info [302], [303]
RP5063 Drug Info [304], [305]
S-(-)-sulpiride Drug Info [306], [307], [301]
Sertindole Drug Info [308], [309]
SLV-307 Drug Info [310]
Sulpiride Drug Info [306], [307], [301]
Thiethylperazine Drug Info [311], [312]
Thioridazine Drug Info [313], [314]
Thiothixene Drug Info [315]
Tiapride Drug Info [307]
Tolazoline Drug Info [316]
Umespirone Drug Info [317]
Zuclopenthixol Drug Info [318], [268]
[3H]N-methylspiperone Drug Info [319]
[3H]nemonapride Drug Info [320]
[3H]raclopride Drug Info [321]
[3H]spiperone Drug Info [322]
Agonist (-)-3PPP, Maryland Drug Info [25]
(-)-N-porphynorapomorphine Drug Info [323]
7-trans-OH-PIPAT Drug Info [324]
AM-831 Drug Info [325]
AMR-103 Drug Info [326]
Aplindore fumarate Drug Info [327], [25]
Apomorphine Drug Info [328]
Aripiprazole Drug Info [329]
Bromocriptine Drug Info [330], [331], [332]
Cabergoline Drug Info [333], [334]
Carmoxirole Drug Info [335]
CQA 206-291 Drug Info [336]
Dihydroergotamine Drug Info [337]
Dihydroergotoxine Drug Info [22]
Dopamine Drug Info [338], [339]
Entacapone+levodopa+carbidopa Drug Info [340]
Ephedrine Drug Info [29]
Ergonovine Drug Info [341]
Fencamfamine Drug Info [342]
Intranasal apomorphine Drug Info [343]
JNJ-37822681 Drug Info [344]
Lisuride Drug Info [345], [346], [347]
LP-12 Drug Info [348]
LP-211 Drug Info [244]
LP-44 Drug Info [348]
Lu-02-750 Drug Info [349]
Mephentermine Drug Info [350]
Mesoridazine Drug Info [351]
Metaraminol Drug Info [352]
Methamfetamine Drug Info [48]
Methyldopa Drug Info [353]
MLS1547 Drug Info [354]
N-0923 Drug Info [106]
Naphazoline Drug Info [355]
Nemonapride Drug Info [25]
NOLOMIROLE HYDROCHLORIDE Drug Info [356], [2]
Olanzapine Drug Info [59]
Pardoprunox Drug Info [71]
PD 128907 Drug Info [357]
PF-03800130 Drug Info [273]
Phenylephrine Drug Info [358], [359]
piribedil Drug Info [360]
Quetiapine Drug Info [268], [361]
Quinagolide Drug Info [362]
Rotigitine Drug Info [11]
SAVOXEPIN MESYLATE Drug Info [363], [2]
Sumanirole Drug Info [106]
Talipexole Drug Info [364]
Uinagolide Drug Info [362]
UNC0006 Drug Info [365]
UNC9975 Drug Info [365]
UNC9994 Drug Info [365]
WS-50030 Drug Info [273]
XP-21279 Drug Info [366]
Y-20024 Drug Info [367], [2]
Ziprasidone Drug Info [368]
Modulator Abaperidone Drug Info [369]
ATI-9242 Drug Info [370]
BAM-1110 Drug Info
Bifeprunox Drug Info
BIM23A760 Drug Info [111]
BIMG80 Drug Info [371]
Bis(olanzapine) pamoate monohydrate Drug Info [2]
Cariprazine Drug Info [14]
CGP-25454A Drug Info [372]
CGS-15873A Drug Info [373], [2]
CLR-3001 Drug Info [374]
CP-903397 Drug Info [375]
Declopramide Drug Info [376]
Denopamine Drug Info [3]
Docarpamine Drug Info [3]
Dopexamine Drug Info [3]
DU-29894 Drug Info [377]
E-2040 Drug Info [378]
Etrabamine Drug Info [379]
F-15063 Drug Info
FOSOPAMINE Drug Info [380], [2]
Ibopamine hci Drug Info [381], [3]
Levodopa Drug Info [38]
Levomepromazine Drug Info [382]
Lu-AE04621 Drug Info [383]
Lurasidone hydrochloride Drug Info [41], [42]
LY-243062 Drug Info [384]
Mazapertine succinate Drug Info
Naxagolide Drug Info [385]
NGD-93-1 Drug Info [386]
NNC-22-0031 Drug Info [174]
Ocaperidone Drug Info [119]
OPC-34712 Drug Info
Ordopidine Drug Info [387]
Org-10490 Drug Info [382]
PD-143188 Drug Info [388]
Perazine Drug Info [389], [2]
Pergolide Drug Info [382]
PF-217830 Drug Info
Piperacetazine Drug Info [382]
PNU-96391A Drug Info [177]
Pramipexole Drug Info [382]
Pridopidine Drug Info [390]
RBP-7000 Drug Info [391]
Romergoline Drug Info [392]
Ropinirole Drug Info [382]
RWJ-25730 Drug Info
S-18327 Drug Info [393]
S32504 Drug Info [136]
Sarizotan Drug Info
SDZ-208911 Drug Info [394], [2]
SDZ-GLC-756 Drug Info [395]
SDZ-MAR-327 Drug Info
SEL-73 Drug Info [273]
Sibenadet Drug Info
SLV-310 Drug Info
SLV-313 Drug Info
SSR-181507 Drug Info
YKP-1358 Drug Info [396]
Zicronapine Drug Info [397]
Binder Droperidol Drug Info [398]
Molindone Drug Info [399], [400]
SKL-10406 Drug Info [401]
Y-931 Drug Info [25]
ZD-3638 Drug Info [25]
Stimulator Pseudoephedrine Drug Info [402], [403]
Modulator (allosteric modulator) SB269652 Drug Info [404]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson&#039
s disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
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