Drug General Information |
Drug ID |
D00HUV
|
Former ID |
DNC003771
|
Drug Name |
[2-(1H-Benzoimidazol-4-yloxy)-ethyl]-benzyl-amine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
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Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C16H17N3O
|
Canonical SMILES |
C1=CC=C(C=C1)CNCCOC2=CC=CC3=C2N=CN3
|
InChI |
1S/C16H17N3O/c1-2-5-13(6-3-1)11-17-9-10-20-15-8-4-7-14-16(15)19-12-18-14/h1-8,12,17H,9-11H2,(H,18,19)
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InChIKey |
XQWCSGWUJUEAQM-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
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D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
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D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04015:Rap1 signaling pathway
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cAMP signaling pathway
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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GPCRs, Other
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References |
REF 1 | Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8.New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. |