| Drug General Information |
| Drug ID |
D07XYQ
|
| Former ID |
DNC011876
|
| Drug Name |
R-N-PROPYLNORAPOMORPHINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H21NO2
|
| Canonical SMILES |
CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O
|
| InChI |
1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3/t15-/m1/s1
|
| InChIKey |
BTGAJCKRXPNBFI-OAHLLOKOSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
|
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cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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Gap junction
|
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Dopaminergic synapse
|
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Parkinson's disease
|
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Cocaine addiction
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Amphetamine addiction
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Morphine addiction
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Alcoholismhsa04015:Rap1 signaling pathway
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Alcoholism
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PANTHER Pathway
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Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
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G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
|
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Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
|
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GPCR ligand binding
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | J Med Chem. 2008 Feb 28;51(4):983-7. Epub 2008 Feb 6.Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity. |
|---|
