Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N6FZ
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| Former ID |
DIB015711
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| Drug Name |
WS-50030
|
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| Synonyms |
WS-50030; Dual dopamine D2 partial agonist/serotonin reuptake inhibitor (schizophrenia); Dual dopamine D2 partial agonist/serotonin reuptake inhibitor (schizophrenia), Pfizer/Solvay
|
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| Drug Type |
Small molecular drug
|
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| Indication | Schizophrenia [ICD9: 295; ICD10:F20] | Investigative | [1] | ||
| Company |
Wyeth
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H25N3O2
|
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| Canonical SMILES |
C1=C(CCCN2CCN(c3cccc4c3oc(=O)[nH]4)CC2)c2c(C1)cccc2
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Agonist | [1] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215). | ||||
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