| Drug General Information |
| Drug ID |
D04PBD
|
| Former ID |
DIB020383
|
| Drug Name |
MLS1547
|
| Synonyms |
MLS000051547
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H19ClN4O
|
| InChI |
InChI=1S/C19H19ClN4O/c20-16-12-14(19(25)18-15(16)4-3-7-22-18)13-23-8-10-24(11-9-23)17-5-1-2-6-21-17/h1-7,12,25H,8-11,13H2
|
| InChIKey |
OPEJNANYABTIGC-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
3666529, 4110443, 4255655, 5124868, 8765477, 26632487, 26979540, 42137345, 47532652, 48128068, 53294329, 56381260, 87828176, 105262217, 110236273, 113635326, 121333729, 124818295, 130974503, 140708888, 144069819, 160671913, 164918354, 165230863, 167738012, 179413908, 238388307, 246464530, 252166581, 252450483, 252543692, 252617271
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Agonist |
[1]
|
|---|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Dopaminergic synapse
|
|
Parkinson's disease
|
|
Cocaine addiction
|
|
Alcoholism
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Dopamine receptor mediated signaling pathway
|
|
Nicotine pharmacodynamics pathway
|
|
Reactome
|
Dopamine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | Discovery and characterization of a G protein-biased agonist that inhibits beta-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014 Jul;86(1):96-105. |
|---|
