Drug General Information |
Drug ID |
D09EEV
|
Former ID |
DIB010577
|
Drug Name |
Declopramide
|
Synonyms |
IBD therapy, Active Biotech; Inflammatory bowel disease therapy, Active Biotech; OXi-104; IMO-B project, Active Biotech; 3-CPA; 3-chloroprocainamide
|
Drug Type |
Small molecular drug
|
Indication |
Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]
|
Discontinued in Phase 2 |
[1]
|
Company |
OXiGENE Inc
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C13H20ClN3O
|
Canonical SMILES |
C(=O)(c1cc(c(cc1)N)Cl)NCCN(CC)CC
|
CAS Number |
CAS 891-60-1
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
D(2) dopamine receptor |
Target Info |
Modulator |
[2]
|
Muscarinic acetylcholine receptor M1 |
Target Info |
Modulator |
[2]
|
KEGG Pathway
|
Rap1 signaling pathway
|
cAMP signaling pathway
|
Neuroactive ligand-receptor interaction
|
Gap junction
|
Dopaminergic synapse
|
Parkinson's disease
|
Cocaine addiction
|
Alcoholismhsa04020:Calcium signaling pathway
|
PI3K-Akt signaling pathway
|
Cholinergic synapse
|
Regulation of actin cytoskeleton
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
Dopamine receptor mediated signaling pathway
|
Nicotine pharmacodynamics pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
Reactome
|
Dopamine receptors
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
G alpha (q) signalling events
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
Monoamine GPCRs
|
GPCRs, Class A Rhodopsin-like
|
Genes and (Common) Pathways Underlying Drug Addiction
|
GPCR ligand binding
|
GPCR downstream signaling
|
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
|
Calcium Regulation in the Cardiac Cell
|
Regulation of Actin Cytoskeleton
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
Secretion of Hydrochloric Acid in Parietal Cells
|
References |
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007055) |
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REF 2 | Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. |