| Drug General Information |
| Drug ID |
D09EEV
|
| Former ID |
DIB010577
|
| Drug Name |
Declopramide
|
| Synonyms |
IBD therapy, Active Biotech; Inflammatory bowel disease therapy, Active Biotech; OXi-104; IMO-B project, Active Biotech; 3-CPA; 3-chloroprocainamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]
|
Discontinued in Phase 2 |
[1]
|
|---|
| Company |
OXiGENE Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H20ClN3O
|
| Canonical SMILES |
C(=O)(c1cc(c(cc1)N)Cl)NCCN(CC)CC
|
| CAS Number |
CAS 891-60-1
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Modulator |
[2]
|
|---|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Dopaminergic synapse
|
|
Parkinson's disease
|
|
Cocaine addiction
|
|
Alcoholismhsa04020:Calcium signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeleton
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Dopamine receptor mediated signaling pathway
|
|
Nicotine pharmacodynamics pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
Reactome
|
Dopamine receptors
|
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
Regulation of Actin Cytoskeleton
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Secretion of Hydrochloric Acid in Parietal Cells
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007055) |
|---|
| REF 2 | Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. |
|---|
