Drug General Information |
Drug ID |
D0Q2GP
|
Former ID |
DNC011498
|
Drug Name |
ISOLOXAPINE
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C18H18ClN3O
|
Canonical SMILES |
CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)OC4=CC=CC=C42
|
InChI |
1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3
|
InChIKey |
AWHNHDGHHNGACT-UHFFFAOYSA-N
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PubChem Compound ID |
|
Target and Pathway |
Target(s) |
D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
D(1B) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M5 |
Target Info |
Inhibitor |
[1]
|
D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M4 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04020:Calcium signaling pathway
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Cholinergic synapse
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Regulation of actin cytoskeleton
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Insulin secretion
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretionhsa04020:Calcium signaling pathway
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cAMP signaling pathway
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PI3K-Akt signaling pathway
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
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Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04015:Rap1 signaling pathway
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04020:Calcium signaling pathway
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Amphetamine addiction
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Morphine addiction
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP05912:Dopamine receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathway
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PathWhiz Pathway
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Gastric Acid ProductionPW000564:Muscle/Heart ContractionPW000440:Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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Acetylcholine regulates insulin secretion
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G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (s) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP58:Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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Gastrin-CREB signalling pathway via PKC and MAPK
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Integration of energy metabolism
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
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Secretion of Hydrochloric Acid in Parietal Cells
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GPCR downstream signalingWP58:Monoamine GPCRs
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
|
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
|
References |
REF 1 | J Med Chem. 1981 Sep;24(9):1021-6.Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. |