Drug Information

Drug General Information
Drug ID
D0Q2GP
Former ID
DNC011498
Drug Name
ISOLOXAPINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533577]
Structure
Download
2D MOL

3D MOL
Formula
C18H18ClN3O
Canonical SMILES
CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)OC4=CC=CC=C42
InChI
1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3
InChIKey
AWHNHDGHHNGACT-UHFFFAOYSA-N
PubChem Compound ID
10381810
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [533577]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [533577]
D(1B) dopamine receptor Target Info Inhibitor [533577]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [533577]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [533577]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [533577]
D(4) dopamine receptor Target Info Inhibitor [533577]
D(2) dopamine receptor Target Info Inhibitor [533577]
Dopamine D1 receptor Target Info Inhibitor [533577]
Muscarinic acetylcholine receptor M4 Target Info Inhibitor [533577]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04020:Calcium signaling pathway
Amphetamine addiction
Morphine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP05912:Dopamine receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart ContractionPW000440:Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP58:Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
References
Ref 533577J Med Chem. 1981 Sep;24(9):1021-6.Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.
Ref 533577J Med Chem. 1981 Sep;24(9):1021-6.Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.