Drug Information
Drug General Information | |||||
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Drug ID |
D01HZE
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Former ID |
DNC012749
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Drug Name |
BRL-25594
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Canonical SMILES |
COC1=CC(=C(C=C1C(=O)NC2CC3CCC(C2)N3C(=O)C4=CC=CC=C4)Cl)<br />N
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InChI |
1S/C22H24ClN3O3/c1-29-20-12-19(24)18(23)11-17(20)21(27)25-14-9-15-7-8-16(10-14)26(15)22(28)13-5-3-2-4-6-13/h2-6,11-12,14-16H,7-10,24H2,1H3,(H,25,27)
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InChIKey |
YFYKDXUABDOBBU-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | D(2) dopamine receptor | Target Info | Inhibitor | [1] | |
KEGG Pathway | Rap1 signaling pathway | ||||
cAMP signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Dopaminergic synapse | |||||
Parkinson's disease | |||||
Cocaine addiction | |||||
Alcoholism | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Dopamine receptor mediated signaling pathway | |||||
Nicotine pharmacodynamics pathway | |||||
Reactome | Dopamine receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | Hypothetical Network for Drug Addiction | ||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Genes and (Common) Pathways Underlying Drug Addiction | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
Nicotine Activity on Dopaminergic Neurons | |||||
References | |||||
REF 1 | J Med Chem. 2003 Feb 27;46(5):702-15.Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity. | ||||
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