Drug Information

Drug General Information
Drug ID
D01HZE
Former ID
DNC012749
Drug Name
BRL-25594
Indication Discovery agent Investigative [526544]
Structure
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2D MOL

3D MOL
Canonical SMILES
COC1=CC(=C(C=C1C(=O)NC2CC3CCC(C2)N3C(=O)C4=CC=CC=C4)Cl)<br />N
InChI
1S/C22H24ClN3O3/c1-29-20-12-19(24)18(23)11-17(20)21(27)25-14-9-15-7-8-16(10-14)26(15)22(28)13-5-3-2-4-6-13/h2-6,11-12,14-16H,7-10,24H2,1H3,(H,25,27)
InChIKey
YFYKDXUABDOBBU-UHFFFAOYSA-N
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [526544]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 526544J Med Chem. 2003 Feb 27;46(5):702-15.Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.
Ref 526544J Med Chem. 2003 Feb 27;46(5):702-15.Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.

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