Drug General Information |
Drug ID |
D03YXB
|
Former ID |
DNC013744
|
Drug Name |
(+)-(1R,1'S)-berbamunine hydrochloride
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C36H41ClN2O6
|
Canonical SMILES |
CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC5C6=<br />CC(=C(C=C6CCN5C)OC)O)O)O)OC.Cl
|
InChI |
1S/C36H40N2O6.ClH/c1-37-13-11-24-18-34(42-3)32(40)20-27(24)29(37)15-22-5-8-26(9-6-22)44-36-17-23(7-10-31(36)39)16-30-28-21-33(41)35(43-4)19-25(28)12-14-38(30)2;/h5-10,17-21,29-30,39-41H,11-16H2,1-4H3;1H/t29-,30+;/m0./s1
|
InChIKey |
JOARPLDATXXJHM-XCCPJCIBSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Calcium signaling pathway
|
cAMP signaling pathway
|
Neuroactive ligand-receptor interaction
|
Gap junction
|
Dopaminergic synapse
|
Parkinson's disease
|
Cocaine addiction
|
Amphetamine addiction
|
Morphine addiction
|
Alcoholismhsa04015:Rap1 signaling pathway
|
Alcoholism
|
PANTHER Pathway
|
Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
Dopamine receptor mediated signaling pathway
|
Nicotine pharmacodynamics pathway
|
PathWhiz Pathway
|
Dopamine Activation of Neurological Reward System
|
Reactome
|
Dopamine receptors
|
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
|
G alpha (i) signalling events
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
Monoamine GPCRs
|
GPCRs, Class A Rhodopsin-like
|
Genes and (Common) Pathways Underlying Drug Addiction
|
GPCR ligand binding
|
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
|
GPCR downstream signaling
|
Nicotine Activity on Dopaminergic Neurons
|
References |
REF 1 | Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. |