| Drug General Information |
| Drug ID |
D0OG0R
|
| Former ID |
DNC010089
|
| Drug Name |
WAY-208466
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H18FN3O2S
|
| InChI |
InChI=1S/C17H18FN3O2S/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14/h3-8,11-12H,9-10H2,1-2H3
|
| InChIKey |
SFSFIDVAEMDPIP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
15348898, 22703302, 33970805, 78654914, 103701666, 104155189, 134347294, 143335390, 229868871, 245213710, 252166639
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 7 receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[2]
|
| 5-hydroxytryptamine 6 receptor |
Target Info |
Inhibitor |
[2]
|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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Ras signaling pathway
|
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Calcium signaling pathway
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Neuroactive ligand-receptor interaction
|
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Serotonergic synapsehsa04015:Rap1 signaling pathway
|
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cAMP signaling pathway
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Gap junction
|
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Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Alcoholismhsa04020:Calcium signaling pathway
|
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Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
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Serotonergic synapsehsa04020:Calcium signaling pathway
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
|
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PathWhiz Pathway
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Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
|
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Reactome
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Serotonin receptors
|
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G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
|
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling events
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WikiPathways
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Serotonin Receptor 4/6/7 and NR3C Signaling
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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Nicotine Activity on Dopaminergic NeuronsWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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SIDS Susceptibility Pathways
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8429). |
|---|
| REF 2 | Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. Epub 2009 May 29.Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. |
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