Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0K1DC
|
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| Former ID |
DIB013719
|
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| Drug Name |
Romergoline
|
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| Synonyms |
FCE-23884
|
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| Drug Type |
Small molecular drug
|
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| Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Discontinued in Phase 2 | [1] | ||
| Company |
Pharmacia & Upjohn AB
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C20H22N4O2
|
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| Canonical SMILES |
C12=C[C@H](CN([C@@H]1Cc1c3c2cccc3[nH]c1)C)CN1CC(=O)NC(=<br />O)C1
|
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| CAS Number |
CAS 107052-56-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001388) | ||||
| REF 2 | CA patent application no. 648479, Implants for the treatment of dopamine associated states. | ||||
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