Drug Information
Drug General Information | |||||
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Drug ID |
D0K1DC
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Former ID |
DIB013719
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Drug Name |
Romergoline
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Synonyms |
FCE-23884
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Drug Type |
Small molecular drug
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Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Discontinued in Phase 2 | [1] | ||
Company |
Pharmacia & Upjohn AB
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Structure |
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Download2D MOL |
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Formula |
C20H22N4O2
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Canonical SMILES |
C12=C[C@H](CN([C@@H]1Cc1c3c2cccc3[nH]c1)C)CN1CC(=O)NC(=<br />O)C1
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CAS Number |
CAS 107052-56-2
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | D(2) dopamine receptor | Target Info | Modulator | [2] | |
KEGG Pathway | Rap1 signaling pathway | ||||
cAMP signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Dopaminergic synapse | |||||
Parkinson's disease | |||||
Cocaine addiction | |||||
Alcoholism | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Dopamine receptor mediated signaling pathway | |||||
Nicotine pharmacodynamics pathway | |||||
Reactome | Dopamine receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | Hypothetical Network for Drug Addiction | ||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Genes and (Common) Pathways Underlying Drug Addiction | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
Nicotine Activity on Dopaminergic Neurons | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001388) | ||||
REF 2 | CA patent application no. 648479, Implants for the treatment of dopamine associated states. | ||||
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