Drug General Information |
Drug ID |
D0M2BB
|
Former ID |
DNC006668
|
Drug Name |
1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C20H22N4
|
Canonical SMILES |
C1CN(CCN1CC2=CC=C(C=C2)N3C=CC=N3)C4=CC=CC=C4
|
InChI |
1S/C20H22N4/c1-2-5-19(6-3-1)23-15-13-22(14-16-23)17-18-7-9-20(10-8-18)24-12-4-11-21-24/h1-12H,13-17H2
|
InChIKey |
PKQSDHHTBMYENT-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04015:Rap1 signaling pathway
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cAMP signaling pathway
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04020:Calcium signaling pathway
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Amphetamine addiction
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Morphine addiction
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Alcoholism
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (s) signalling events
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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References |
REF 1 | Bioorg Med Chem Lett. 2006 Jun 1;16(11):2955-9. Epub 2006 Mar 24.Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. |