Drug General Information |
Drug ID |
D0U6IL
|
Former ID |
DNC012638
|
Drug Name |
1-Aminomethyl-isochroman-5,6-diol
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C10H13NO3
|
Canonical SMILES |
C1COC(C2=C1C(=C(C=C2)O)O)CN
|
InChI |
1S/C10H13NO3/c11-5-9-6-1-2-8(12)10(13)7(6)3-4-14-9/h1-2,9,12-13H,3-5,11H2
|
InChIKey |
JBSRTZUQAXYSQB-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04020:Calcium signaling pathway
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Amphetamine addiction
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Morphine addiction
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Alcoholism
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (s) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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References |
REF 1 | J Med Chem. 1990 Nov;33(11):2948-50.(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |