Drug General Information |
Drug ID |
D0HV3A
|
Former ID |
DNC011857
|
Drug Name |
FLUMEZAPINE
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C17H19FN4S
|
Canonical SMILES |
CC1=CC2=C(NC3=C(C=CC(=C3)F)N=C2S1)N4CCN(CC4)C
|
InChI |
1S/C17H19FN4S/c1-11-9-13-16(22-7-5-21(2)6-8-22)19-15-10-12(18)3-4-14(15)20-17(13)23-11/h3-4,9-10,19H,5-8H2,1-2H3
|
InChIKey |
CABBDKQGQDDPQA-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
D(4) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
Dopamine D1 receptor |
Target Info |
Inhibitor |
[2]
|
Muscarinic acetylcholine receptor M4 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M5 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
D(3) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
D(1B) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
Dopaminergic synapsehsa04015:Rap1 signaling pathway
|
cAMP signaling pathway
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04020:Calcium signaling pathway
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Amphetamine addiction
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Morphine addiction
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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Cholinergic synapse
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
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PI3K-Akt signaling pathway
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Regulation of actin cytoskeleton
|
Insulin secretion
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Salivary secretion
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Gastric acid secretion
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Pancreatic secretionhsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04020:Calcium signaling pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP05912:Dopamine receptor mediated signaling pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward SystemPW000564:Muscle/Heart ContractionPW000565:Gastric Acid Production
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (s) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
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Acetylcholine regulates insulin secretion
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G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (s) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
|
GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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GPCR downstream signalingWP58:Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
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GPCRs, OtherWP58:Monoamine GPCRs
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Secretion of Hydrochloric Acid in Parietal Cells
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Integration of energy metabolism
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References |
REF 1 | J Med Chem. 1989 Dec;32(12):2573-82.Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. |
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REF 2 | J Med Chem. 1982 Oct;25(10):1133-40.Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems. |