Drug Information

Drug General Information
Drug ID
D0Y0ER
Former ID
DAP000315
Drug Name
Thiethylperazine
Synonyms
ETHYLTHIOPERAZINE; Theithylperazine; Thiethylperazinum; Thiethylpipezazine; Thioethylperazine; Tietilperazina; Torecan; Tietilperazina [DCIT]; Thiethylperazinum [INN-Latin]; Torecan (TN); Thiethylperazine (USAN/INN); Thiethylperazine [USAN:INN:BAN]; Norzine (*Dimaleate*); GS-95 (*Dimaleate*); 10H-Phenothiazine, 2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-, (Z)-2-butenedioate (1:2); 2-(Ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine; 2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine; 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine; 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine; 3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine
Drug Type
Small molecular drug
Indication Nausea; Vomiting [ICD9: 787, 787.0; ICD10:R11] Approved [538460], [542328]
Therapeutic Class
Antiemetics
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C22H29N3S2
InChI
InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
InChIKey
XCTYLCDETUVOIP-UHFFFAOYSA-N
CAS Number
CAS 1420-55-9
PubChem Compound ID
5440
PubChem Substance ID
9342, 618292, 5646731, 7849413, 7980773, 8153348, 10507857, 14879091, 29224490, 46506502, 48416610, 49699402, 50006536, 56352874, 57322781, 76368511, 85209578, 103462495, 104309248, 125089234, 125823178, 127339724, 127339725, 127339726, 134222490, 134337627, 134979014, 135739860, 137001505, 142971091, 160963719, 162939803, 178103879, 179116916, 184527123, 198985013, 226432954, 249932754, 251971089, 252655192
ChEBI ID
ChEBI:9544
SuperDrug ATC ID
R06AD03
SuperDrug CAS ID
cas=001420559
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Antagonist [537675], [537780]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 538460FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012753.
Ref 542328(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7306).
Ref 537675Torecan-induced neuroleptic malignant syndrome. Harefuah. 1990 May 15;118(10):576-8.
Ref 537780Antiemetic specificity of dopamine antagonists. Psychopharmacology (Berl). 1982;78(3):210-3.

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