Drug General Information |
Drug ID |
D0LV7U
|
Former ID |
DNC007774
|
Drug Name |
1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one
|
Drug Type |
Small molecular drug
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Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C23H29N3O2
|
Canonical SMILES |
COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)CC4=CC=CC=C43
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InChI |
1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-20-9-3-2-8-19(20)18-23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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InChIKey |
VJMHUOSOEAGNQW-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
D(1B) dopamine receptor |
Target Info |
Inhibitor |
[1]
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D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04020:Calcium signaling pathway
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cAMP signaling pathway
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Dopaminergic synapsehsa04015:Rap1 signaling pathway
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholism
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PANTHER Pathway
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Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP58:Monoamine GPCRs
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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References |
REF 1 | Bioorg Med Chem. 2007 Sep 1;15(17):5811-8. Epub 2007 Jun 7.Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand. |