Drug General Information |
Drug ID |
D0TU5W
|
Former ID |
DNC003543
|
Drug Name |
4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
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Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C19H20ClN3
|
Canonical SMILES |
C1CN(CCN1CC2=CC=CC=C2)C3=C(C=CC4=C3C=CN4)Cl
|
InChI |
1S/C19H20ClN3/c20-17-6-7-18-16(8-9-21-18)19(17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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InChIKey |
IRFLVVGRMBDQSJ-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
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D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
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D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04015:Rap1 signaling pathway
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cAMP signaling pathway
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholism
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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References |
REF 1 | Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80.New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. |