Drug Information
Drug General Information | |||||
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Drug ID |
D0W4YO
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Former ID |
DNC004256
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Drug Name |
NOCICEPTIN
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Indication | Headache [ICD9: 339, 784.0; ICD10:G43-G44, R51] | Phase 1 | [523563] | ||
Structure |
Download2D MOL |
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Formula |
C79H129N27O22
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Mu-type opioid receptor | Target Info | Inhibitor | [529276] | |
Nociceptin receptor | Target Info | Inhibitor | [529719] | ||
NetPath Pathway | TCR Signaling Pathway | ||||
Pathway Interaction Database | IL4-mediated signaling events | ||||
References | |||||
Ref 529276 | J Med Chem. 2008 Feb 28;51(4):1058-62. Epub 2008 Jan 31.Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists. | ||||
Ref 529719 | Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. Epub 2008 Sep 9.Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. |
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