TTD | Drug: D0X5WS

Drug General Information
Drug ID	D0X5WS
Former ID	DNC001227
Drug Name	Ro-64-6198
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539044]
Structure		Download 2D MOL 3D MOL
Formula	C26H31N3O
InChI	InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1
InChIKey	JLFMYEAXZNPWBK-REWPJTCUSA-N
PubChem Compound ID	9844019
PubChem Substance ID	14805894, 15676330, 24141633, 44942090, 49684211, 79939977, 134338851, 134340441, 134359331, 135650922, 160675774, 162223587, 163369826, 228367009
Target and Pathway
Target(s)	Nociceptin receptor	Target Info	Agonist	[535745]
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539044	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1684).
Ref 535745	The nociceptin receptor as a potential target in drug design. Drug News Perspect. 2001 Aug;14(6):335-45.

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Drug Information