Drug General Information
Drug ID	D0X8KC
Former ID	DNC000255
Drug Name	Arsenite
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535043]
Structure		Download 2D MOL 3D MOL
Formula	AsHO2
Canonical SMILES	O[As]=O
InChI	1S/AsHO2/c2-1-3/h(H,2,3)
InChIKey	XHTRYVMKFMUJLU-UHFFFAOYSA-N
CAS Number	CAS 10102-53-1
PubChem Compound ID	24577
PubChem Substance ID	623501, 5341080, 8167965, 24705099, 29291640, 50167595, 104360014, 135022021, 137133115, 242502173
ChEBI ID	ChEBI:29866
SuperDrug ATC ID	L01XX27
SuperDrug CAS ID	cas=001327533
Target and Pathway
Target(s)	Inhibitor of nuclear factor kappa-B kinase	Target Info	Inhibitor	[535043]
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	Activation of NF-kappaB in B cells
	NOD1/2 Signaling Pathway
	RIP-mediated NFkB activation via ZBP1
	AKT phosphorylates targets in the cytosol
	p75NTR recruits signalling complexes
	NF-kB is activated and signals survival
	FCERI mediated NF-kB activation
	Interleukin-1 signaling
	Regulation of TNFR1 signaling
	TNFR1-induced NFkappaB signaling pathway
	IKBKB deficiency causes SCID
	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
	IkBA variant leads to EDA-ID
	Dectin-1 mediated noncanonical NF-kB signaling
	CLEC7A (Dectin-1) signaling
	Constitutive Signaling by AKT1 E17K in Cancer
	NIK-->noncanonical NF-kB signaling
	MAP3K8 (TPL2)-dependent MAPK1/3 activation
	TRAF6 mediated IRF7 activation
	TRAF6 mediated NF-kB activation
	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
	Negative regulators of RIG-I/MDA5 signaling
	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
	IRAK1 recruits IKK complex
	IKK complex recruitment mediated by RIP1
	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
WikiPathways	Toll-like receptor signaling pathway
	Estrogen signaling pathway
	TCR Signaling Pathway
	Insulin Signaling
	IL-4 Signaling Pathway
	MAPK Signaling Pathway
	NLR Proteins
	Hair Follicle Development: Induction (Part 1 of 3)
	MyD88 cascade initiated on plasma membrane
	Cardiac Hypertrophic Response
	Cytosolic sensors of pathogen-associated DNA
	MyD88 dependent cascade initiated on endosome
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
	MyD88:Mal cascade initiated on plasma membrane
	Fc epsilon receptor (FCERI) signaling
	MyD88-independent cascade
	Signaling by the B Cell Receptor (BCR)
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	Structural Pathway of Interleukin 1 (IL-1)
	EBV LMP1 signaling
	Polycystic Kidney Disease Pathway
	Apoptosis
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	BDNF signaling pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TNF alpha Signaling Pathway
	B Cell Receptor Signaling Pathway
	IL17 signaling pathway
	TWEAK Signaling Pathway
	Leptin signaling pathway
	RANKL/RANK Signaling Pathway
	Signalling by NGF
	IL-1 signaling pathway
	TCR signaling
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Interleukin-1 signaling
	Apoptosis Modulation and Signaling
	Type II diabetes mellitus
	MicroRNAs in cardiomyocyte hypertrophy
	Regulation of toll-like receptor signaling pathway
	Osteopontin Signaling
	NOD pathway
References
Ref 535043	Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6.
Ref 535043	Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6.

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