Drug Information

Drug General Information
Drug ID
D0Y5TL
Former ID
DNC005808
Drug Name
ALLOXAZINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467797]
Structure
Download
2D MOL

3D MOL
Formula
C10H6N4O2
InChI
InChI=1S/C10H6N4O2/c15-9-7-8(13-10(16)14-9)12-6-4-2-1-3-5(6)11-7/h1-4H,(H2,12,13,14,15,16)
InChIKey
HAUGRYOERYOXHX-UHFFFAOYSA-N
PubChem Compound ID
5372720
PubChem Substance ID
451914, 473315, 4956928, 6156892, 7778045, 10523977, 10560890, 10589628, 11110697, 11216386, 11402151, 11657363, 15365357, 17404721, 17425201, 17425202, 24277695, 24890699, 25632054, 26753529, 39392322, 47331796, 48259515, 48259516, 48448037, 49645529, 50105899, 50105900, 53777264, 57362399, 80096949, 85083500, 85090530, 85208946, 85230889, 88297412, 88521338, 89449665, 90340898, 92220724, 92225576, 92303577, 99017118, 99226622, 103264398, 104839904, 105206877, 114174506, 121361102, 124504616
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Inhibitor [527823]
Adenosine A2a receptor Target Info Inhibitor [527823]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholismhsa04015:Rap1 signaling pathway
cAMP signaling pathway
Parkinson's disease
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR downstream signaling
GPCRs, Other
References
Ref 467797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 456).
Ref 527823J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

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