Drug Information

Drug General Information
Drug ID
D0Y8UM
Former ID
DIB016202
Drug Name
Debio 1143
Indication Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86] Phase 1/2 [524580]
Company
Debiopharma
Target and Pathway
Target(s) Inhibitor of apoptosis protein 1 Target Info Inhibitor [533079], [544451]
X-linked inhibitor of apoptosis protein Target Info Inhibitor [533079], [544451]
Inhibitor of apoptosis protein 2 Target Info Inhibitor [533079], [544451]
KEGG Pathway NF-kappa B signaling pathway
Ubiquitin mediated proteolysis
Apoptosis
Focal adhesion
NOD-like receptor signaling pathway
TNF signaling pathway
Toxoplasmosis
Pathways in cancer
Transcriptional misregulation in cancer
Small cell lung cancerhsa04064:NF-kappa B signaling pathway
HTLV-I infection
Hippo signaling pathway
Small cell lung cancer
NetPath Pathway IL5 Signaling Pathway
IL1 Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Notch Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
CCKR signaling map STP00006:Apoptosis signaling pathwayP00006:Apoptosis signaling pathway
CCKR signaling map ST
Pathway Interaction Database CD40/CD40L signaling
FAS (CD95) signaling pathway
TNF receptor signaling pathway
Ceramide signaling pathway
p75(NTR)-mediated signaling
C-MYB transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosisp75ntrpathway:p75(NTR)-mediated signaling
BMP receptor signaling
Caspase Cascade in Apoptosis
TGF-beta receptor signalingnfkappabcanonicalpathway:Canonical NF-kappaB pathway
Reactome NOD1/2 Signaling Pathway
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
IKK complex recruitment mediated by RIP1R-HSA-111463:SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Deactivation of the beta-catenin transactivating complex
Regulation of necroptotic cell deathR-HSA-111465:Apoptotic cleavage of cellular proteins
IKK complex recruitment mediated by RIP1
WikiPathways Focal Adhesion
Apoptosis
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
Apoptosis Modulation and SignalingWP3286:Copper homeostasis
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
NOD pathwayWP306:Focal Adhesion
Apoptotic execution phase
References
Ref 524580ClinicalTrials.gov (NCT02022098) Debio 1143-201 Dose-finding and Efficacy Phase I/II Trial. U.S. National Institutes of Health.
Ref 533079Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro. Am J Cancer Res. 2014 Nov 19;4(6):943-51. eCollection 2014.
Ref 544451Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro. Am J Cancer Res. 2014; 4(6): 943-951.

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