Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-ethyl-piperazin-1-yl]-(2,3-dimethyl-phenyl)-methanone | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-((1E,3E)-hepta-1,3-dienyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 2-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-[(3,5-dimethyl-isoxazol-4-ylmethyl)-amide] | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-yl ester | Drug Info |
| Ftase --- FPTase | Cyclic peptide analogue | Drug Info |
| Ftase --- FPTase | 2-(2-Phenyl-1H-indol-3-yl)-N,N-bis-pyridin-3-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| Ftase --- FPTase | 2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-chloro-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-3-yl-ethanone | Drug Info |
| Ftase --- FPTase | N-Furan-3-ylmethyl-N-isopropyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| Ftase --- FPTase | (2-Benzylamino-phenyl)-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylmethyl-amide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| Ftase --- FPTase | 7-Bromo-3-(2-chloro-benzyl)-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid phenylamide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(3,4-Dichloro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 6-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| Ftase --- FPTase | 5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-(1-Benzenesulfonyl-piperidin-4-yl)-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 15,16,18-trimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | 19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | 2-(2-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-tetradecanoic acid | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(3-(1H-imidazol-5-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(5-chloro-thiophen-2-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | ethyl 2-(5-methyl-3-(3-(1-methyl-1H-imidazol-5-yl)propyl)-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetate | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-{3-[1-methyl-2-oxo-3-(3,3,3-trifluoro-propyl)-azepan-3-yl]-phenoxy}-benzonitrile | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-piperidin-1-yl-methanone | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-ethoxy-pyridin-3-ylmethyl ester | Drug Info |
| Ftase --- FPTase | (2S)-2-(2-(3-((1H-imidazol-5-yl)methyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoic acid | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-3-yl)-amide | Drug Info |
| Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-(3-(2-oxoazepan-3-yl)phenoxy)benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{(S)-2-[(S)-2-Amino-3-(3H-imidazol-4-yl)-propionylamino]-3-methyl-butyrylamino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(3-quinolin-2-ylmethyl-3H-imidazol-4-yl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | Pseudopeptide derivative | Drug Info |
| Ftase --- FPTase | SID146411 | Drug Info |
| Ftase --- FPTase | C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo[1,2-a]quinolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[2-(1-methyl-1H-imidazol-4-yl)-ethyl]-amide} | Drug Info |
| Ftase --- FPTase | 3-Biphenyl-4-ylethynyl-4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(4-(aminomethyl)benzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazine-1-carboxylic acid tert-butyl ester | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid aminomethyl-amide | Drug Info |
| Ftase --- FPTase | 1-(((2R,3R)-3-(2,4-dichlorobenzyloxy)-5-fluoro-2,3-dihydrobenzo[b]thiophen-2-yl)methyl)-1H-imidazole | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-phenyl-methanone | Drug Info |
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