Target Information

Target General Infomation
Target ID
T88338
Former ID
TTDS00217
Target Name
23S rRNA
Synonyms
Plastid 23S rRNA; RrnL
Target Type
Successful
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Gram-positive bacterial infection [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104]
Pneumonia; Bacterial infections [ICD9: 001-009, 001-139, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104, 480-486, 770.0; ICD10: J12-J18]
Target Validation
T88338
Drugs and Mode of Action
Drug(s) Linezolid Drug Info Approved Bacterial infections [536773]
Macrolides Drug Info Approved Bacterial infections [536854]
Spiramycin Drug Info Approved Bacterial infections [551871]
Thiamphenicol Drug Info Approved Bacterial infections [551871]
Cethromycin Drug Info Phase 3 Pneumonia; Bacterial infections [536773]
Oxazolidinones Drug Info Phase 2 Gram-positive bacterial infection [522273]
Inhibitor Cethromycin Drug Info [536773]
Oxazolidinones Drug Info [534883]
Binder Linezolid Drug Info [537206]
Macrolides Drug Info [536854]
Micrococcin Drug Info [535329]
Spiramycin Drug Info [535329]
Thiostrepton Drug Info [535329]
Modulator Thiamphenicol Drug Info [529611]
References
Ref 522273ClinicalTrials.gov (NCT00646958) Safety and Efficacy Study of Oxazolidinones to Treat Uncomplicated Skin Infections. U.S. National Institutes of Health.
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 529611The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-9-13.
Ref 534883Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46.
Ref 535329The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 537206Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23. Epub 2009 Apr 6.

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