Target Information
Target General Infomation | |||||
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Target ID |
T97174
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Former ID |
TTDS00481
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Target Name |
Mannose-6-phosphate receptor
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Gene Name |
M6PR
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Synonyms |
46kDa mannose 6-phosphate receptor; CD-MPR; CDMan-6-P receptor; MPR 46; MPR46; MPRD; M6PR
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Target Type |
Successful
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Disease | Pompe's disease; Type 2 glycogen storage disease [ICD9:271; ICD10: E74.02, E74.0] | ||||
Function |
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
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UniProt ID | |||||
Sequence |
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSF
ESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIML IYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACS PEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGC DFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM |
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Drugs and Mode of Action | |||||
Pathways | |||||
References |
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