Target Information
Target General Infomation | |||||
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Target ID |
T84560
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Former ID |
TTDR00083
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Target Name |
Mitochondrial uncoupling protein 2
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Gene Name |
UCP2
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Synonyms |
UCP 2; UCPH; UCP2
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Target Type |
Clinical Trial
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Disease | Obesity [ICD9: 278; ICD10: E66] | ||||
Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
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BioChemical Class |
Mitochondrial carrier
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UniProt ID | |||||
Sequence |
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR
GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA ACTSREAPF |
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Drugs and Mode of Action | |||||
Pathways | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | ||||
WikiPathways | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Electron Transport Chain | |||||
References | |||||
Ref 534866 | Development of beta 3-adrenoceptor agonists for the treatment of obesity and diabetes--an update. Diabetes Metab. 1999 Mar;25(1):11-21. |
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