Target Information

Target General Infomation
Target ID
T25164
Former ID
TTDR00747
Target Name
Flavohemoglobin
Gene Name
hmp
Synonyms
Dihydropteridine reductase; Ferrisiderophore reductase B; HMP; Hemoglobin-like protein; NO oxygenase; NOD; Nitric oxide dioxygenase; hmp
Target Type
Research
Function
Various electron acceptors arealso reduced by HMP in vitro, including dihydropterine, ferrisiderophores, ferric citrate, cytochrome c, nitrite, S-nitrosoglutathione, and alkylhydroperoxides. However, it is unknown if these reactions are of any biological significance in vivo.
BioChemical Class
Oxidoreductases acting on paired donors
UniProt ID
P24232
EC Number
EC 1.6.99.7
Sequence
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNA
IAAYASNIENLPALLPAVEKIAQKHTSFQIKPEQYNIVGEHLLATLDEMFSPGQEVLDAW
GKAYGVLANVFINREAEIYNENASKAGGWEGTRDFRIVAKTPRSALITSFELEPVDGGAV
AEYRPGQYLGVWLKPEGFPHQEIRQYSLTRKPDGKGYRIAVKREEGGQVSNWLHNHANVG
DVVKLVAPAGDFFMAVADDTPVTLISAGVGQTPMLAMLDTLAKAGHTAQVNWFHAAENGD
VHAFADEVKELGQSLPRFTAHTWYRQPSEADRAKGQFDSEGLMDLSKLEGAFSDPTMQFY
LCGPVGFMQFTAKQLVDLGVKQENIHYECFGPHKVL
Inhibitor 2-(N-Morpholino)-Ethanesulfonic Acid Drug Info [551393]
Flavin-Adenine Dinucleotide Drug Info [551393]
Heme Drug Info [551374]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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