Drug General Information
Drug ID
Former ID
Drug Name
Flavin-Adenine Dinucleotide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468245]


CAS Number
CAS 146-14-5
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) NRH dehydrogenase [quinone] 2 Target Info Inhibitor [551393]
Nitric-oxide synthase, brain Target Info Inhibitor [551393]
Dihydropyrimidine dehydrogenase [NADP+] Target Info Inhibitor [551393]
Dihydrolipoamide dehydrogenase, mitochondrial Target Info Inhibitor [551393]
UDP-N-acetylenolpyruvylglucosamine reductase Target Info Inhibitor [551393]
Fumarate reductase flavoprotein subunit Target Info Inhibitor [551393]
Xanthine dehydrogenase/oxidase Target Info Inhibitor [551393]
Glutathione reductase, mitochondrial Target Info Inhibitor [551393]
NAD(P)H dehydrogenase [quinone] 1 Target Info Inhibitor [551393]
Trypanothione reductase Target Info Inhibitor [551393]
Amine oxidase [flavin-containing] A Target Info Inhibitor [551393]
Flavohemoglobin Target Info Inhibitor [551393]
Thioredoxin reductase, cytoplasmic Target Info Inhibitor [551393]
Amine oxidase [flavin-containing] B Target Info Inhibitor [551393]
BioCyc Pathway Citrulline-nitric oxide cyclePWY-7209:Pyrimidine ribonucleosides degradation
Thymine degradation
Uracil degradationPWY-6353:Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Retinoate biosynthesis IIPWY66-401:Superpathway of tryptophan utilization
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)hsa00240:Pyrimidine metabolism
beta-Alanine metabolism
Pantothenate and CoA biosynthesis
Drug metabolism - other enzymes
Metabolic pathwayshsa00230:Purine metabolism
Caffeine metabolism
Peroxisomehsa00130:Ubiquinone and other terpenoid-quinone biosynthesishsa00260:Glycine, serine and threonine metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa00260:Glycine, serine and threonine metabolism
NetPath Pathway EGFR1 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_16:IL4 Signaling Pathway
PANTHER Pathway CCKR signaling map STP02771:Pyrimidine MetabolismP02723:Adenine and hypoxanthine salvage pathway
Purine metabolismP00001:Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Validated transcriptional targets of TAp63 isoformsalphasynuclein_pathway:Alpha-synuclein signaling
PathWhiz Pathway Arginine and Proline MetabolismPW000011:Beta-Alanine Metabolism
Pyrimidine MetabolismPW000015:Caffeine Metabolism
Purine MetabolismPW000047:Vitamin K MetabolismPW000043:Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-74259:Purine catabolismR-HSA-181430:Norepinephrine Neurotransmitter Release Cycle
WikiPathways Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter ActivityWP1851:Metabolism of nucleotides
Fluoropyrimidine ActivityWP408:Oxidative Stress
Metabolism of nucleotides
Selenium Micronutrient NetworkWP697:Estrogen metabolism
Oxidative Stress
Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
Aryl Hydrocarbon Receptor Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Metabolism of amino acids and derivatives
Aryl Hydrocarbon Receptor
Dopamine metabolism
Arylhydrocarbon receptor (AhR) signaling pathwayWP706:SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter ActivityWP465:Tryptophan metabolism
Ref 468245(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5184).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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