Target Information

Target General Infomation
Target ID
T31230
Former ID
TTDS00307
Target Name
Fumarate reductase flavoprotein subunit
Gene Name
frdA
Synonyms
FRDA; Fumarate reductase; frdA
Target Type
Successful
Disease Dutch elm disease; Helminth infection [ICD9:001-139; ICD10: B81-B83, A00-B99]
Mature gastrointestinal nematode infections [ICD9: 127; ICD10: B77-B81]
Trichuris trichiura infection [ICD9: 127.3; ICD10: B79]
Function
Two distinct, membrane-bound, fad-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; The fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.
BioChemical Class
Oxidoreductases acting on CH-CH group of donors
UniProt ID
O06913
EC Number
EC 1.3.99.1
Sequence
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKK
SEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVN
GEHVTITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKD
MLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASA
LETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELAS
RDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADS
KEQTKDNMQGVPANEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGE
AACWDLHGFNRLGGNSVSEAVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHF
LLHNEGKEDVYEIRERMKEVMDEKVGVFREGKRLEEALKELQELYARSKNICVKNKVLHN
NPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQ
DMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRIEV
QHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHELLDQHNANLKGEHHE
Drugs and Mode of Action
Drug(s) Morantel tartrate Drug Info Approved Mature gastrointestinal nematode infections [551034]
Oxantel pamoate Drug Info Approved Trichuris trichiura infection [535056]
Thiabendazole Drug Info Approved Dutch elm disease; Helminth infection [538473], [542326], [551871]
Inhibitor 2,3-DIMETHYL-1,4-NAPHTHOQUINONE Drug Info [551374]
2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE Drug Info [551374]
2-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOL Drug Info [551374]
Citraconic acid Drug Info [551391]
Flavin-Adenine Dinucleotide Drug Info [551393]
Fumarate Drug Info [551393]
Heme Drug Info [551374]
Malate Like Intermediate Drug Info [551391]
Morantel tartrate Drug Info [535056], [537845]
Oxantel pamoate Drug Info [535056]
Thiabendazole Drug Info [535056]
References
Ref 535056Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87.
Ref 538473FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016096.
Ref 542326(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7304).
Ref 551034Morantel tartrate. Canadian Food Inspection Agency. Government of Canada. 2010-08.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535056Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87.
Ref 537845Fumarate reductase: a target for therapeutic intervention against Helicobacter pylori. Arch Biochem Biophys. 1995 Aug 1;321(1):153-9.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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