Target Information
Target General Infomation | |||||
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Target ID |
T84581
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Former ID |
TTDS00276
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Target Name |
Thioredoxin reductase, cytoplasmic
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Gene Name |
TXNRD1
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Synonyms |
Cytosolic thioredoxin reductase; TR; TR1; Thioredoxin reductase; TrxR; TXNRD1
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Target Type |
Successful
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Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
Malaria [ICD10: B54] | |||||
BioChemical Class |
Oxidoreductases acting on a sulfur group of donors
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Target Validation |
T84581
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UniProt ID | |||||
EC Number |
EC 1.8.1.9
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Sequence |
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG |
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Drugs and Mode of Action | |||||
Inhibitor | 3-formyl-4-phenyl-1,2,5-oxadiazole 2-oxide | Drug Info | [530387] | ||
4,6-dinitrobenzo[c][1,2,5]thiadiazole | Drug Info | [528012] | |||
5,8-Dihydroxy-1,4-naphthoquinone | Drug Info | [536365] | |||
Bis(2,4-dinitrophenyl)sulfane | Drug Info | [528012] | |||
Flavin-Adenine Dinucleotide | Drug Info | [551393] | |||
Fotemustine | Drug Info | [551393] | |||
Spermidine | Drug Info | [551393] | |||
References | |||||
Ref 528012 | Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. Epub 2006 Feb 3.Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. | ||||
Ref 530387 | J Med Chem. 2009 Oct 22;52(20):6474-83.Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. |
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