Target Information
Target General Infomation | |||||
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Target ID |
T04741
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Former ID |
TTDR00945
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Target Name |
Phosphoribosylaminoimidazolecarboxamide formyltransferase
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Gene Name |
ATIC
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Synonyms |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; AICARFT; ATIC
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Target Type |
Research
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Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
BioChemical Class |
Methyltransferase superfamily
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Target Validation |
T04741
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UniProt ID | |||||
EC Number |
EC 2.1.2.3
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Sequence |
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH |
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Inhibitor | FAICAR | Drug Info | [528699] | ||
NSC-126445 | Drug Info | [527350] | |||
NSC-26699 | Drug Info | [527350] | |||
NSC-292213 | Drug Info | [527350] | |||
NSC-30171 | Drug Info | [527350] | |||
NSC-324572 | Drug Info | [527350] | |||
NSC-37031 | Drug Info | [527350] | |||
NSC-37173 | Drug Info | [527350] | |||
NSC-45592 | Drug Info | [527350] | |||
NSC-47729 | Drug Info | [527350] | |||
NSC-58046 | Drug Info | [527350] | |||
NSC-88915 | Drug Info | [527350] | |||
References |
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