Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T48614
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| Former ID |
TTDC00228
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| Target Name |
mRNA of Eukaryotic translation initiation factor 4E
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| Gene Name |
EIF4E
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| Synonyms |
EIF-4E; EIF-4F 25 kDa subunit; MRNA cap-binding protein; EIF4E
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| Target Type |
Research
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| Function |
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
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| Target Validation |
T48614
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| UniProt ID | |||||
| Sequence |
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV |
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| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | RNA transport | ||||
| HIF-1 signaling pathway | |||||
| mTOR signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| Insulin signaling pathway | |||||
| PANTHER Pathway | p38 MAPK pathway | ||||
| CCKR signaling map ST | |||||
| Pathway Interaction Database | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | ||||
| Validated targets of C-MYC transcriptional activation | |||||
| mTOR signaling pathway | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| PathWhiz Pathway | Leucine Stimulation on Insulin Signaling | ||||
| Reactome | ISG15 antiviral mechanism | ||||
| mTORC1-mediated signalling | |||||
| WikiPathways | Interferon type I signaling pathways | ||||
| Hypertrophy Model | |||||
| Insulin Signaling | |||||
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | |||||
| ISG15 antiviral mechanism | |||||
| Deadenylation-dependent mRNA decay | |||||
| Structural Pathway of Interleukin 1 (IL-1) | |||||
| BDNF signaling pathway | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| Signaling by Insulin receptor | |||||
| Processing of Capped Intron-Containing Pre-mRNA | |||||
| Eukaryotic Translation Initiation | |||||
| Translation Factors | |||||
| References | |||||
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