Target Information

Target General Infomation
Target ID
T22995
Former ID
TTDI02090
Target Name
Hepcidin
Gene Name
HAMP
Synonyms
Hepc20; Hepc25; Hepcidin20; LEAP1; Liverexpressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor; HAMP
Target Type
Clinical Trial
Disease Anemia [ICD9: 280-285; ICD10: D50-D64]
Function
Has strong antimicrobial activity against E.coli ML35P N.cinereaand weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).
BioChemical Class
Hepcidin family
UniProt ID
P81172
Sequence
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRD
THFPICIFCCGCCHRSKCGMCCKT
Drugs and Mode of Action
Drug(s) NOX-H94 Drug Info Phase 2 Anemia [532202]
Hepcidin mab Drug Info Phase 1 Anemia [523448]
Inhibitor NOX-H94 Drug Info [532202]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
WikiPathways Iron metabolism in placenta
References
Ref 523448ClinicalTrials.gov (NCT01340976) A Phase 1 Study of LY2787106 in Cancer and Anemia. U.S. National Institutes of Health.
Ref 532202The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013 Mar 21;121(12):2311-5.
Ref 532202The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013 Mar 21;121(12):2311-5.
Ref 544389The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161.

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