Target Information

Target General Infomation
Target ID
T94977
Former ID
TTDNR00652
Target Name
Cardiotrophin-1
Gene Name
CTF1
Synonyms
CT-1; CTF1
Target Type
Clinical Trial
Disease Acute liver failure [ICD10: K72]
Function
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
BioChemical Class
Cytokine: interleukin
UniProt ID
Q16619
Sequence
MSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPS
FSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLR
RLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGL
YREWLSRTEGDLGQLLPGGSA
Drugs and Mode of Action
Drug(s) Cardiotrophin-1 Drug Info Phase 1 Acute liver failure [468092], [523426]
Stimulator Cardiotrophin-1 Drug Info [1572591]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
References
Ref 468092(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4906).
Ref 523426ClinicalTrials.gov (NCT01334697) Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of Cardiotrophin-1 in Healthy Volunteers. U.S. National Institutes of Health.
Ref
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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