Drug General Information |
Drug ID |
D02BBT
|
Former ID |
DNC014207
|
Drug Name |
2-Bromo-N-(2-morpholinoethyl)nicotinamide
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C12H16BrN3O2
|
Canonical SMILES |
C1COCCN1CCNC(=O)C2=C(N=CC=C2)Br
|
InChI |
1S/C12H16BrN3O2/c13-11-10(2-1-3-14-11)12(17)15-4-5-16-6-8-18-9-7-16/h1-3H,4-9H2,(H,15,17)
|
InChIKey |
FKGFLJZEVNCAEZ-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Amine oxidase [flavin-containing] A |
Target Info |
Inhibitor |
[1]
|
Amine oxidase [flavin-containing] B |
Target Info |
Inhibitor |
[1]
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BioCyc Pathway
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Superpathway of tryptophan utilization
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Dopamine degradation
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Putrescine degradation III
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Noradrenaline and adrenaline degradation
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Serotonin degradation
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Superpathway of melatonin degradation
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Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
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Tryptophan degradation via tryptamine
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KEGG Pathway
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Glycine, serine and threonine metabolism
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Arginine and proline metabolism
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Histidine metabolism
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Tyrosine metabolism
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Phenylalanine metabolism
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Tryptophan metabolism
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Drug metabolism - cytochrome P450
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Metabolic pathways
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Serotonergic synapse
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Dopaminergic synapse
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Cocaine addiction
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Amphetamine addiction
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Alcoholismhsa00260:Glycine, serine and threonine metabolism
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Alcoholism
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NetPath Pathway
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IL4 Signaling Pathway
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PANTHER Pathway
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Adrenaline and noradrenaline biosynthesis
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5-Hydroxytryptamine degredation
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Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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Dopamine receptor mediated signaling pathway
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Pathway Interaction Database
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Alpha-synuclein signaling
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PathWhiz Pathway
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Histidine Metabolism
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Tyrosine Metabolism
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Glycine and Serine Metabolism
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Reactome
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Norepinephrine Neurotransmitter Release Cycle
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WikiPathways
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SIDS Susceptibility Pathways
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Biogenic Amine Synthesis
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Oxidative Stress
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Dopamine metabolism
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Phase 1 - Functionalization of compounds
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Neurotransmitter Release Cycle
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Neurotransmitter Clearance In The Synaptic Cleft
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Serotonin Transporter ActivityWP465:Tryptophan metabolism
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References |
REF 1 | Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. Epub 2010 Jan 4.Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. |