Drug Information

Drug General Information
Drug ID
D03HFG
Former ID
DAP000740
Drug Name
Fluvoxamine
Synonyms
Dumirox; Dumyrox; Faverin; Floxyfral; Fluvoxamina; Fluvoxaminum; Maveral; Fluvoxamina [INN-Spanish]; Fluvoxamine (INN); Fluvoxamine [INN:BAN]; Fluvoxamine-CR; Fluvoxaminum [INN-Latin]; Luvox (TN); (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime; 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine; 2-[({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [536120], [542200]
Therapeutic Class
Antidepressants
Company
IVAX Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C15H21F3N2O2
InChI
InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+
InChIKey
CJOFXWAVKWHTFT-XSFVSMFZSA-N
CAS Number
CAS 54739-18-3
PubChem Compound ID
5324346
PubChem Substance ID
9774, 7979296, 11571264, 14899201, 17425133, 26751469, 39297346, 47276707, 47350437, 47425375, 48020069, 48020070, 49699379, 50002999, 50103976, 51005940, 57361188, 85788587, 90340960, 92718857, 93166767, 93310594, 96024678, 99373241, 103112227, 103214033, 103937470, 114182507, 117504588, 124749760, 124883444, 124883445, 124883446, 126628425, 126651435, 126666543, 131318468, 134338027, 134339778, 135004455, 137002947, 139157656, 143472592, 144204388, 160963524, 162182990, 163392547, 163842794, 164841793, 164841794
ChEBI ID
ChEBI:5138
SuperDrug ATC ID
N06AB08
SuperDrug CAS ID
cas=054739183
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [537565], [537730]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 536120Autism spectrum disorders: emerging pharmacotherapy. Expert Opin Emerg Drugs. 2005 Aug;10(3):521-36.
Ref 542200(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7189).
Ref 537565Changes of functional MRI findings in a patient whose pathological gambling improved with fluvoxamine. Yonsei Med J. 2009 Jun 30;50(3):441-4. Epub 2009 Jun 24.
Ref 537730Placebo controlled double-blind trial of fluvoxamine maleate in the obese. J Psychosom Res. 1986;30(2):143-6.

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