Drug Information

Drug General Information
Drug ID
D05NIE
Former ID
DNC007708
Drug Name
4-(2-(aminomethyl)phenyl)-1-benzylpiperidin-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528781]
Structure
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2D MOL

3D MOL
Formula
C19H24N2O
Canonical SMILES
C1CN(CCC1(C2=CC=CC=C2CN)O)CC3=CC=CC=C3
InChI
1S/C19H24N2O/c20-14-17-8-4-5-9-18(17)19(22)10-12-21(13-11-19)15-16-6-2-1-3-7-16/h1-9,22H,10-15,20H2
InChIKey
RPBRGKBDJGSAFB-UHFFFAOYSA-N
PubChem Compound ID
44430036
Target and Pathway
Target(s) Nociceptin receptor Target Info Inhibitor [528781]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528781Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
Ref 528781Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.

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