Drug General Information
Drug ID
D0T3HK
Former ID
DNC009123
Drug Name
1-(pyridin-4-yl)piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530029]
Structure
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2D MOL

3D MOL

Formula
C9H13N3
Canonical SMILES
C1CN(CCN1)C2=CC=NC=C2
InChI
1S/C9H13N3/c1-3-10-4-2-9(1)12-7-5-11-6-8-12/h1-4,11H,5-8H2
InChIKey
OQZBAQXTXNIPRA-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Phospholipase D1 Target Info Inhibitor [530029]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways
Ras signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Endocytosis
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
GnRH signaling pathway
Pathways in cancer
Pancreatic cancer
Choline metabolism in cancer
PANTHER Pathway Angiogenesis
Ras Pathway
Pathway Interaction Database RhoA signaling pathway
Arf6 trafficking events
CDC42 signaling events
Arf6 downstream pathway
mTOR signaling pathway
ErbB1 downstream signaling
IL8- and CXCR1-mediated signaling events
Alpha-synuclein signaling
Reactome Role of phospholipids in phagocytosis
WikiPathways EGF/EGFR Signaling Pathway
TSH signaling pathway
References
Ref 530029Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. Epub 2009 Mar 6.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Ref 530029Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. Epub 2009 Mar 6.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.

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