Drug Information

Drug General Information
Drug ID
D0Z5GR
Former ID
DNC010336
Drug Name
1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530596]
Structure
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2D MOL

3D MOL
Formula
C15H16ClN3O
Canonical SMILES
C1CN(CCN1)C2=C(N=CC=C2)OC3=CC=CC=C3Cl
InChI
1S/C15H16ClN3O/c16-12-4-1-2-6-14(12)20-15-13(5-3-7-18-15)19-10-8-17-9-11-19/h1-7,17H,8-11H2
InChIKey
LVSZWRFDLAUNPF-UHFFFAOYSA-N
PubChem Compound ID
46230818
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [530596]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [530596]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530596Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
Ref 530596Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.

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