Drug Information

Drug General Information
Drug ID
D0RD0N
Former ID
DAP000036
Drug Name
Neomycin
Synonyms
Actilin; Actiline; Antibiotique; Endomixin; Enterfram; Fradiomycin; Fradiomycinum; Framicetina; Framycetin; Framycetine; Framycetinum; Framygen; Fraquinol; Myacine; Myacyne; Mycifradin; Myciguent; NMY; Neobiotic; Neobrettin; Neolate; Neomas; Neomcin; Neomicina; Neomin; Neomycine;Neomycinum; Nivemycin; PIMAVECORT; Soframycin; Soframycine; Tuttomycin; VONAMYCIN; Fradiomycin B; NEOMYCIN AND POLYMYXIN B SULFATES; NEOMYCIN B; NEOMYCIN SULFATE; Neomicina [DCIT]; Neomycin B sulfate; Neomycin solution; Soframycin Ophthalmic; Vonamycin powder V; Antibiotic 10676; Antibiotic produced by Streptomyces decaris. Neomycin B; Framicetina [INN-Spanish]; Framycetin (INN); Framycetine [INN-French]; Framycetinum [INN-Latin]; Mycifradin (TN); Neo-Fradin; Neo-Rx; Neomycine [INN-French]; Neomycinum [INN-Latin]; USAF CB-19; Framycetin [INN:BAN:DCF]; Neo-Fradin (TN); Neo-Tab (TN); BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG; BDG-(1-4)NEB-(5-1)RIB-(3-1)NED; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol; D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy
Drug Type
Small molecular drug
Indication Acute hepatic failure; Alcoholic cirrhosis of liver [ICD9: 570, 571.1; ICD10:K71, K72] Approved [538196], [542095]
Therapeutic Class
Antibiotics
Company
Geofman
Structure
Download
2D MOL

3D MOL
Formula
C23H46N6O13
InChI
InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey
PGBHMTALBVVCIT-VCIWKGPPSA-N
CAS Number
CAS 1404-04-2
PubChem Compound ID
8378
PubChem Substance ID
4872, 600744, 7886109, 7886110, 7889440, 8027095, 8155893, 11108087, 14789604, 16359677, 17398248, 24886366, 24897464, 26705169, 26713687, 26715354, 29227077, 46505525, 46508892, 47589231, 48185242, 48259497, 48416318, 48498331, 49699023, 49703385, 49997098, 49997102, 50124333, 53788467, 80496344, 85164700, 92308991, 104317690, 123097006, 124576752, 124766144, 126666617, 127317005, 127317006, 127317007, 127317008, 127317009, 127317010, 127317011, 127317012, 127317013, 127317014, 127317015, 127317016
SuperDrug ATC ID
A01AB08; A07AA01; B05CA09; D06AX04; J01GB05; R02AB01; S01AA03; S02AA07; S03AA01
SuperDrug CAS ID
cas=001404042
Target and Pathway
Target(s) 30S ribosomal subunit Target Info Binder [536559]
References
Ref 538196FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 060304.
Ref 542095(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 709).
Ref 536559Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9. Epub 2007 Dec 5.

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